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Chemical Compound Review

Cortisol     (8R,9R,10R,11S,13S,14S,17R)- 11,17...

Synonyms: Acticort, Aquacort, Cetacort, Colocort, Cortanal, ...
 
 
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Disease relevance of Topicort

 

Psychiatry related information on Topicort

 

High impact information on Topicort

 

Chemical compound and disease context of Topicort

 

Biological context of Topicort

 

Anatomical context of Topicort

 

Associations of Topicort with other chemical compounds

 

Gene context of Topicort

  • The effect of DSCG was not specific for CD40-mediated induction of IgE isotype switching because DSCG inhibited IgE synthesis as well as S mu-->S epsilon deletional switch recombination induced by hydrocortisone and IL-4 in B cells [44].
  • In patients receiving daily glucocorticoid therapy (greater than 15 mg prednisolone or an equivalent daily dose), the plasma ACTH and cortisol responses to hCRF-LVP were suppressed 2 wk to 1 mo after the beginning of glucocorticoid administration but partially improved at 2-10 mo, and was markedly suppressed several years later [45].
  • In conclusion, 11 beta-HSD2 activity is reduced in cholestasis, which results in MR activation by cortisol [46].
  • Placenta and endometrium carry out steroidogenic biotransformation reactions such as 6-beta-hydroxylation of cortisol, a reaction characteristic of the dominant family of cytochromes P450 in human liver, CYP3A [47].
  • The best evidence for this is from studies on IgE synthesis by IL-4-plus hydrocortisone-stimulated umbilical cord blood lymphocytes, which do not produce detectable amounts of IFN-gamma [48].
  • Although cortisol blunted the amplitude of GnRH-induced LH pulses within 1-2 h, the amount of GnRH receptor mRNA or protein was not affected over this time frame [49].
 

Analytical, diagnostic and therapeutic context of Topicort

References

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