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Chemical Compound Review

Cortisol     (8R,9R,10R,11S,13S,14S,17R)- 11,17...

Synonyms: Acticort, Aquacort, Cetacort, Colocort, Cortanal, ...
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Disease relevance of Topicort


Psychiatry related information on Topicort


High impact information on Topicort


Chemical compound and disease context of Topicort


Biological context of Topicort


Anatomical context of Topicort


Associations of Topicort with other chemical compounds


Gene context of Topicort

  • The effect of DSCG was not specific for CD40-mediated induction of IgE isotype switching because DSCG inhibited IgE synthesis as well as S mu-->S epsilon deletional switch recombination induced by hydrocortisone and IL-4 in B cells [44].
  • In patients receiving daily glucocorticoid therapy (greater than 15 mg prednisolone or an equivalent daily dose), the plasma ACTH and cortisol responses to hCRF-LVP were suppressed 2 wk to 1 mo after the beginning of glucocorticoid administration but partially improved at 2-10 mo, and was markedly suppressed several years later [45].
  • In conclusion, 11 beta-HSD2 activity is reduced in cholestasis, which results in MR activation by cortisol [46].
  • Placenta and endometrium carry out steroidogenic biotransformation reactions such as 6-beta-hydroxylation of cortisol, a reaction characteristic of the dominant family of cytochromes P450 in human liver, CYP3A [47].
  • The best evidence for this is from studies on IgE synthesis by IL-4-plus hydrocortisone-stimulated umbilical cord blood lymphocytes, which do not produce detectable amounts of IFN-gamma [48].
  • Although cortisol blunted the amplitude of GnRH-induced LH pulses within 1-2 h, the amount of GnRH receptor mRNA or protein was not affected over this time frame [49].

Analytical, diagnostic and therapeutic context of Topicort


  1. Evidence for two subtypes of Cushing's disease based on the analysis of episodic cortisol secretion. Van Cauter, E., Refetoff, S. N. Engl. J. Med. (1985) [Pubmed]
  2. Synthesis and secretion of insulin-like growth factor II by a leiomyosarcoma with associated hypoglycemia. Daughaday, W.H., Emanuele, M.A., Brooks, M.H., Barbato, A.L., Kapadia, M., Rotwein, P. N. Engl. J. Med. (1988) [Pubmed]
  3. The corticotropin-releasing factor stimulation test. An aid in the evaluation of patients with Cushing's syndrome. Chrousos, G.P., Schulte, H.M., Oldfield, E.H., Gold, P.W., Cutler, G.B., Loriaux, D.L. N. Engl. J. Med. (1984) [Pubmed]
  4. Food-dependent Cushing's syndrome mediated by aberrant adrenal sensitivity to gastric inhibitory polypeptide. Reznik, Y., Allali-Zerah, V., Chayvialle, J.A., Leroyer, R., Leymarie, P., Travert, G., Lebrethon, M.C., Budi, I., Balliere, A.M., Mahoudeau, J. N. Engl. J. Med. (1992) [Pubmed]
  5. Abnormal hypothalamic-pituitary-adrenal function in anorexia nervosa. Pathophysiologic mechanisms in underweight and weight-corrected patients. Gold, P.W., Gwirtsman, H., Avgerinos, P.C., Nieman, L.K., Gallucci, W.T., Kaye, W., Jimerson, D., Ebert, M., Rittmaster, R., Loriaux, D.L. N. Engl. J. Med. (1986) [Pubmed]
  6. Measurement of salivary cortisol concentration in the assessment of adrenal function in critically ill subjects: a surrogate marker of the circulating free cortisol. Arafah, B.M., Nishiyama, F.J., Tlaygeh, H., Hejal, R. J. Clin. Endocrinol. Metab. (2007) [Pubmed]
  7. Dietary macronutrient content alters cortisol metabolism independently of body weight changes in obese men. Stimson, R.H., Johnstone, A.M., Homer, N.Z., Wake, D.J., Morton, N.M., Andrew, R., Lobley, G.E., Walker, B.R. J. Clin. Endocrinol. Metab. (2007) [Pubmed]
  8. Assessment of adrenal function in cirrhotic patients: salivary cortisol should be preferred. Galbois, A., Rudler, M., Massard, J., Fulla, Y., Bennani, A., Bonnefont-Rousselot, D., Thibault, V., Reignier, S., Bourrier, A., Poynard, T., Thabut, D. J. Hepatol. (2010) [Pubmed]
  9. Cortisol secretion and metabolism in anorexia nervosa. Boyar, R.M., Hellman, L.D., Roffwarg, H., Katz, J., Zumoff, B., O'Connor, J., Bradlow, H.L., Fukushima, D.K. N. Engl. J. Med. (1977) [Pubmed]
  10. Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men. Van Cauter, E., Leproult, R., Plat, L. JAMA (2000) [Pubmed]
  11. In humans, early cortisol biosynthesis provides a mechanism to safeguard female sexual development. Goto, M., Piper Hanley, K., Marcos, J., Wood, P.J., Wright, S., Postle, A.D., Cameron, I.T., Mason, J.I., Wilson, D.I., Hanley, N.A. J. Clin. Invest. (2006) [Pubmed]
  12. The relations among putative biorisk markers in schizotypal adolescents: minor physical anomalies, movement abnormalities, and salivary cortisol. Mittal, V.A., Dhruv, S., Tessner, K.D., Walder, D.J., Walker, E.F. Biol. Psychiatry (2007) [Pubmed]
  13. Salivary cortisol and psychopathology in children bereaved by the september 11, 2001 terror attacks. Pfeffer, C.R., Altemus, M., Heo, M., Jiang, H. Biol. Psychiatry (2007) [Pubmed]
  14. The association of major depression, conduct disorder, and maternal overcontrol with a failure to show a cortisol buffered response in 4-month-old infants of teenage mothers. Azar, R., Paquette, D., Zoccolillo, M., Baltzer, F., Tremblay, R.E. Biol. Psychiatry (2007) [Pubmed]
  15. Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2. Metherell, L.A., Chapple, J.P., Cooray, S., David, A., Becker, C., Rüschendorf, F., Naville, D., Begeot, M., Khoo, B., Nürnberg, P., Huebner, A., Cheetham, M.E., Clark, A.J. Nat. Genet. (2005) [Pubmed]
  16. Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency. Draper, N., Walker, E.A., Bujalska, I.J., Tomlinson, J.W., Chalder, S.M., Arlt, W., Lavery, G.G., Bedendo, O., Ray, D.W., Laing, I., Malunowicz, E., White, P.C., Hewison, M., Mason, P.J., Connell, J.M., Shackleton, C.H., Stewart, P.M. Nat. Genet. (2003) [Pubmed]
  17. Effects of inhaled glucocorticoids on bone density in premenopausal women. Israel, E., Banerjee, T.R., Fitzmaurice, G.M., Kotlov, T.V., LaHive, K., LeBoff, M.S. N. Engl. J. Med. (2001) [Pubmed]
  18. Identification of virilizing adrenal tumors in hirsute women. Derksen, J., Nagesser, S.K., Meinders, A.E., Haak, H.R., van de Velde, C.J. N. Engl. J. Med. (1994) [Pubmed]
  19. The effect of long-term glucocorticoid therapy on pituitary-adrenal responses to exogenous corticotropin-releasing hormone. Schlaghecke, R., Kornely, E., Santen, R.T., Ridderskamp, P. N. Engl. J. Med. (1992) [Pubmed]
  20. Gastric inhibitory polypeptide-dependent cortisol hypersecretion--a new cause of Cushing's syndrome. Lacroix, A., Bolté, E., Tremblay, J., Dupré, J., Poitras, P., Fournier, H., Garon, J., Garrel, D., Bayard, F., Taillefer, R. N. Engl. J. Med. (1992) [Pubmed]
  21. Corticotropin-releasing hormone stimulation following low-dose dexamethasone administration. A new test to distinguish Cushing's syndrome from pseudo-Cushing's states. Yanovski, J.A., Cutler, G.B., Chrousos, G.P., Nieman, L.K. JAMA (1993) [Pubmed]
  22. Adrenal insufficiency after operative removal of apparently nonfunctioning adrenal adenomas. Huiras, C.M., Pehling, G.B., Caplan, R.H. JAMA (1989) [Pubmed]
  23. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. Annane, D., Sébille, V., Charpentier, C., Bollaert, P.E., François, B., Korach, J.M., Capellier, G., Cohen, Y., Azoulay, E., Troché, G., Chaumet-Riffaut, P., Bellissant, E. JAMA (2002) [Pubmed]
  24. Effects of cortisol on carbohydrate, lipid, and protein metabolism: studies of acute cortisol withdrawal in adrenocortical failure. Christiansen, J.J., Djurhuus, C.B., Gravholt, C.H., Iversen, P., Christiansen, J.S., Schmitz, O., Weeke, J., Jørgensen, J.O., Møller, N. J. Clin. Endocrinol. Metab. (2007) [Pubmed]
  25. Association between the metabolic syndrome and serum cortisol in overweight Latino youth. Weigensberg, M.J., Toledo-Corral, C.M., Goran, M.I. J. Clin. Endocrinol. Metab. (2008) [Pubmed]
  26. Total cortisol in amniotic fluid and fetal lung maturation. de Fencl, M., Tulchinsky, D. N. Engl. J. Med. (1975) [Pubmed]
  27. Cyproheptadine-induced remission of Cushing's disease. Krieger, D.T., Amorosa, L., Linick, F. N. Engl. J. Med. (1975) [Pubmed]
  28. Psychological stress and metabolic control in patients with type I diabetes mellitus. Kemmer, F.W., Bisping, R., Steingrüber, H.J., Baar, H., Hardtmann, F., Schlaghecke, R., Berger, M. N. Engl. J. Med. (1986) [Pubmed]
  29. Decreased hypothalamic gonadotropin-releasing hormone secretion in male marathon runners. MacConnie, S.E., Barkan, A., Lampman, R.M., Schork, M.A., Beitins, I.Z. N. Engl. J. Med. (1986) [Pubmed]
  30. Decreased glucocorticoid receptors in cultured skin fibroblasts from a patient with primary cortisol resistance. Gomi, M., Iida, S., Tsugawa, M., Itoh, Y., Moriwaki, K., Yamashita, S., Tarui, S. N. Engl. J. Med. (1986) [Pubmed]
  31. The differential actions of cortisol on the accumulation of alpha-lactalbumin and casein in midpregnant mouse mammary gland in culture. Ono, M., Oka, T. Cell (1980) [Pubmed]
  32. Effects of cycloheximide on the "autocatalytic" nature of the maturation promoting factor (MPF) in oocytes of Xenopus laevis. Drury, K.C., Schorderet-Slatkine, S. Cell (1975) [Pubmed]
  33. Gluten-sensitive enteropathy. Inhibition by cortisol of the effect of gluten protein in vitro. Katz, A.J., Falchuk, Z.M., Strober, W., Shwachman, H. N. Engl. J. Med. (1976) [Pubmed]
  34. Inhibition of adrenal steroidogenesis by the anesthetic etomidate. Wagner, R.L., White, P.F., Kan, P.B., Rosenthal, M.H., Feldman, D. N. Engl. J. Med. (1984) [Pubmed]
  35. ACTH stimulation tests and plasma dehydroepiandrosterone sulfate levels in women with hirsutism. Siegel, S.F., Finegold, D.N., Lanes, R., Lee, P.A. N. Engl. J. Med. (1990) [Pubmed]
  36. In vitro inhibition of cyclic AMP phosphodiesterase by cortisol. Schmidtke, J., Wienker, T., Flügel, M., Engel, W. Nature (1976) [Pubmed]
  37. Goblet cells in embryonic intestine: accelerated differentiation in culture. Black, B.L., Moog, F. Science (1977) [Pubmed]
  38. An endocrine approach to the control of epidermal growth: serum-free cultivation of human keratinocytes. Maciag, T., Nemore, R.E., Weinstein, R., Gilchrest, B.A. Science (1981) [Pubmed]
  39. Combining growth hormone releasing hormone-arginine and synacthen testing diminishes the cortisol response. Siyambalapitiya, S., Ibbotson, V., Doane, A., Ghigo, E., Campbell, M.J., Ross, R.J. J. Clin. Endocrinol. Metab. (2007) [Pubmed]
  40. Cortisol clearance and associations with insulin sensitivity, body fat and fatty liver in middle-aged men. Holt, H.B., Wild, S.H., Postle, A.D., Zhang, J., Koster, G., Umpleby, M., Shojaee-Moradie, F., Dewbury, K., Wood, P.J., Phillips, D.I., Byrne, C.D. Diabetologia (2007) [Pubmed]
  41. Factors influencing the adrenocorticotropin test: role of contemporary cortisol assays, body composition, and oral contraceptive agents. Klose, M., Lange, M., Rasmussen, A.K., Skakkebaek, N.E., Hilsted, L., Haug, E., Andersen, M., Feldt-Rasmussen, U. J. Clin. Endocrinol. Metab. (2007) [Pubmed]
  42. Urinary cortisol and catecholamine excretion after burn injury in children. Norbury, W.B., Herndon, D.N., Branski, L.K., Chinkes, D.L., Jeschke, M.G. J. Clin. Endocrinol. Metab. (2008) [Pubmed]
  43. Cortisol reduces gonadotropin-releasing hormone pulse frequency in follicular phase ewes: influence of ovarian steroids. Oakley, A.E., Breen, K.M., Clarke, I.J., Karsch, F.J., Wagenmaker, E.R., Tilbrook, A.J. Endocrinology (2009) [Pubmed]
  44. Disodium cromoglycate inhibits S mu-->S epsilon deletional switch recombination and IgE synthesis in human B cells. Loh, R.K., Jabara, H.H., Geha, R.S. J. Exp. Med. (1994) [Pubmed]
  45. Human corticotropin-releasing factor plus lysine vasopressin test during glucocorticoid therapy. Hashimoto, K., Suemaru, S., Takao, T., Sugawara, M., Hattori, T., Kageyama, J., Takahashi, K., Ota, Z. J. Clin. Invest. (1988) [Pubmed]
  46. Reduced activity of 11 beta-hydroxysteroid dehydrogenase in patients with cholestasis. Quattropani, C., Vogt, B., Odermatt, A., Dick, B., Frey, B.M., Frey, F.J. J. Clin. Invest. (2001) [Pubmed]
  47. Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta. Schuetz, J.D., Kauma, S., Guzelian, P.S. J. Clin. Invest. (1993) [Pubmed]
  48. Recombinant interleukin-12 suppresses the synthesis of immunoglobulin E by interleukin-4 stimulated human lymphocytes. Kiniwa, M., Gately, M., Gubler, U., Chizzonite, R., Fargeas, C., Delespesse, G. J. Clin. Invest. (1992) [Pubmed]
  49. Insight into the neuroendocrine site and cellular mechanism by which cortisol suppresses pituitary responsiveness to gonadotropin-releasing hormone. Breen, K.M., Davis, T.L., Doro, L.C., Nett, T.M., Oakley, A.E., Padmanabhan, V., Rispoli, L.A., Wagenmaker, E.R., Karsch, F.J. Endocrinology (2008) [Pubmed]
  50. A randomized trial comparing surgical adrenalectomy with aminoglutethimide plus hydrocortisone in women with advanced breast cancer. Santen, R.J., Worgul, T.J., Samojlik, E., Interrante, A., Boucher, A.E., Lipton, A., Harvey, H.A., White, D.S., Smart, E., Cox, C., Wells, S.A. N. Engl. J. Med. (1981) [Pubmed]
  51. Regulation of pro-opiomelanocortin biosynthesis and processing by transplantation immunity. Zakarian, S., Eleazar, M.S., Silvers, W.K. Nature (1989) [Pubmed]
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