Sulfur analogues of psychotomimetic agents. 3. Ethyl homologues of mescaline and their monothio analogues.
All possible monothio analogues of the mono-, di-, and triethoxy homologues of mescaline have been synthesized and pharmacologically evaluated in man. Modifications at the ring position para to the ethylamine chain, either with a sulfur atom, a longer alkyl chain, or both, lead to compounds of high central nervous system activity. The 4-n-propoxy and 4-n-butoxy homologues and their corresponding 4-thio analogues were also synthesized and pharmacologically evaluated. The propyl homologues retain high potency, but a butyl group (either with or without a sulfur atom) leads to a decrease in activity. The m-ethyl or m-thio analogues retain some central action but the diethoxy and especially the triethoxy homologues are relatively inactive as psychotomimetic drugs.[1]References
- Sulfur analogues of psychotomimetic agents. 3. Ethyl homologues of mescaline and their monothio analogues. Jacob, P., Shulgin, A.T. J. Med. Chem. (1984) [Pubmed]
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