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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Neurogenic sarcomas of the neck in neurofibromatosis.

Based on two observations and a review of the literature, the pathological and clinical findings in sarcomas of the neck in patients with neurofibromatosis are described. Histologically these neurogenic tumours show a manifold picture; in addition to spindle-cell sarcomas pleomorphic structures are to be found, which can be similar to rhabdomyo-, lipo-, chondro-, angio-, or osteogenic sarcomas so that a histological diagnosis of a neurogenic sarcoma cannot always be made without clinical details. Up to the present surgical treatment is preferred; the value of cytostatic therapy and irradiation is controversial. The results of treating these tumours are unsatisfactory. Of 29 cases reported in the literature, only two could be found in which the patient survived without a recurrence for more than five years.[1]


  1. Neurogenic sarcomas of the neck in neurofibromatosis. Martin, G., Kleinsasser, O. Archives of oto-rhino-laryngology. (1981) [Pubmed]
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