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Gene Review

BMP7  -  bone morphogenetic protein 7

Homo sapiens

Synonyms: BMP-7, Bone morphogenetic protein 7, OP-1, OP1, Osteogenic protein 1
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Disease relevance of BMP7

  • Immunohistochemistry of primary and metastatic melanoma also shows increased BMP4 and BMP7 expression compared with nevi [1].
  • In the bone metastasis-derived PC-3 prostate cancer cells, BMP7 induced epithelial-mesenchymal transdifferentiation with classic changes in morphology, motility, invasiveness, and molecular markers [2].
  • Considerable evidences have accumulated to demonstrate that BMP7, a member of the BMP superfamily, attenuates TGFbeta-induced interstitial fibrosis by a reverse of transdifferentiation of renal tubular epithelial cells into mesenchymal cells [3].
  • METHODS: AAV-BMP7 was packaged by infecting the stable cell clone BHK-21 (integrated with recombinant AAV vector plasmid pSNAV-BMP7) with recombinant herpes simplex virus type 1, which expresses AAV-2 Rep and Cap and possesses AAV packaging functions [4].
  • In the ossifying center of the bone rudiments, both OP-1 and TGF-beta inhibited cartilage hypertrophy, growth of the bone collar, and matrix mineralization [5].
  • BMP7 can still counteract the epithelial-to-mesenchymal transition process in the metastatic tumor, positioning BMP7 as a novel therapeutic molecule for treatment of metastatic bone disease [6].

Psychiatry related information on BMP7


High impact information on BMP7


Chemical compound and disease context of BMP7


Biological context of BMP7

  • One extrinsic factor, BMP7, has been shown to specifically affect dendritic morphogenesis; however, the underlying mechanism by which this occurs is unknown [19].
  • Thus, our results reveal a strikingly specific antagonism of BMP7-mediated processes by myostatin and suggest that myostatin is an important regulator of adipogenesis [20].
  • Finally, BMP7 inhibited serum starvation-induced apoptosis in the LNCaP prostate cancer cell line and more remarkably in its bone metastatic variant C4-2B line [2].
  • In all cases, BMP7 induced Smad phosphorylation in a dose-dependent manner, with Smad5 activation clearly demonstrable [2].
  • In this study, combined BMP2 and BMP7 gene transfer was performed to test whether this approach improves osteoblastic differentiation and bone formation compared with single BMP gene transfer [21].

Anatomical context of BMP7

  • In the presence of BMP7, inhibition of alpha5beta1 integrin function still induced the formation of the ectopic joint between proliferating chondrocytes and hypertrophic chondrocytes [22].
  • To determine the relevance of this finding to human prostate cancer, we examined the expression of BMPs and BMP receptors (BMPR) as well as the responsiveness to recombinant human BMP7 in a series of human prostate tumor cell lines [2].
  • Our results suggest that 1,25(OH)2-vitamin D3 modulates in opposite ways the effects of BMP7 and TGFbeta1 on osteoblast differentiation [23].
  • We tested the hypothesis that BMP7 functions by antagonizing profibrogenic events that are induced by transforming growth factor (TGF)-beta in cultured mesangial cells [24].
  • We examined the effects of TGF-beta1, -beta2, BMP2, BMP7 on five epithelial cell lines in vitro [25].

Associations of BMP7 with chemical compounds


Physical interactions of BMP7


Co-localisations of BMP7

  • Phospho-Smads 1/5/8 and ID1 expression largely colocalized with BMP-7 and was also localized in the epithelia of the distal tubule and the CDs [33].

Regulatory relationships of BMP7


Other interactions of BMP7

  • Binding of OP-1/BMP-7 to BMPR-II was also observed in nontransfected cell lines [39].
  • METHODS: Human articular chondrocytes were cultured in alginate beads or as cartilage explants in serum-free medium with or without IGF-1 (100 ng/ml), OP-1 (100 ng/ml), or bFGF (0-100 ng/ml) [34].
  • Osteogenic potential of five different recombinant human bone morphogenetic protein adenoviral vectors in the rat [40].
  • In contrast, changes in BMP5 and BMP7 expression in the perichondrium correspond to altered differentiation states of the flanking chondrocytes [41].
  • As BMP-7 is expressed in the adult human TM in situ, it seems reasonable to assume that it similarly modulates and antagonizes the effects of TGF-beta2 signaling on the tissues of the outflow pathways in vivo [42].

Analytical, diagnostic and therapeutic context of BMP7


  1. Bone morphogenic proteins are overexpressed in malignant melanoma and promote cell invasion and migration. Rothhammer, T., Poser, I., Soncin, F., Bataille, F., Moser, M., Bosserhoff, A.K. Cancer Res. (2005) [Pubmed]
  2. Diverse biological effect and Smad signaling of bone morphogenetic protein 7 in prostate tumor cells. Yang, S., Zhong, C., Frenkel, B., Reddi, A.H., Roy-Burman, P. Cancer Res. (2005) [Pubmed]
  3. A role of BMP in the development of glomerular sclerosis. Ueda, H., Miyazaki, Y., Yokoo, T., Utsunomiya, Y., Kawamura, T., Matsusaka, T., Ichikawa, I., Hosoya, T. Nephrology (Carlton, Vic.) (2005) [Pubmed]
  4. Adeno-associated virus-mediated bone morphogenetic protein-7 gene transfer induces C2C12 cell differentiation into osteoblast lineage cells. Yang, M., Ma, Q.J., Dang, G.T., Ma, K.T., Chen, P., Zhou, C.Y. Acta Pharmacol. Sin. (2005) [Pubmed]
  5. Opposite effects of osteogenic protein and transforming growth factor beta on chondrogenesis in cultured long bone rudiments. Dieudonné, S.C., Semeins, C.M., Goei, S.W., Vukicevic, S., Nulend, J.K., Sampath, T.K., Helder, M., Burger, E.H. J. Bone Miner. Res. (1994) [Pubmed]
  6. BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo. Buijs, J.T., Rentsch, C.A., van der Horst, G., van Overveld, P.G., Wetterwald, A., Schwaninger, R., Henriquez, N.V., Ten Dijke, P., Borovecki, F., Markwalder, R., Thalmann, G.N., Papapoulos, S.E., Pelger, R.C., Vukicevic, S., Cecchini, M.G., Löwik, C.W., van der Pluijm, G. Am. J. Pathol. (2007) [Pubmed]
  7. Type of physical activity, muscle strength, and pubertal stage as determinants of bone mineral density and bone area in adolescent boys. Nordström, P., Pettersson, U., Lorentzon, R. J. Bone Miner. Res. (1998) [Pubmed]
  8. Proceedings of the Osteosarcoma Study Group Meeting (Bethesda, Maryland, January 19, 1977): introduction: treatment of osteogenic sarcoma. Muggia, F.M., Handelsman, H. Cancer treatment reports. (1978) [Pubmed]
  9. The use of neutron beam therapy in the management of locally advanced nonresectable radioresistant tumors. Hendrickson, F.R. CA: a cancer journal for clinicians. (1988) [Pubmed]
  10. Cooperation of BMP7 and SHH in the induction of forebrain ventral midline cells by prechordal mesoderm. Dale, J.K., Vesque, C., Lints, T.J., Sampath, T.K., Furley, A., Dodd, J., Placzek, M. Cell (1997) [Pubmed]
  11. Overexpression of an osteogenic morphogen in fibrodysplasia ossificans progressiva. Shafritz, A.B., Shore, E.M., Gannon, F.H., Zasloff, M.A., Taub, R., Muenke, M., Kaplan, F.S. N. Engl. J. Med. (1996) [Pubmed]
  12. Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm. Liem, K.F., Tremml, G., Roelink, H., Jessell, T.M. Cell (1995) [Pubmed]
  13. Female sex and drug dose as risk factors for late cardiotoxic effects of doxorubicin therapy for childhood cancer. Lipshultz, S.E., Lipsitz, S.R., Mone, S.M., Goorin, A.M., Sallan, S.E., Sanders, S.P., Orav, E.J., Gelber, R.D., Colan, S.D. N. Engl. J. Med. (1995) [Pubmed]
  14. Osteogenic actions of phenytoin in human bone cells are mediated in part by TGF-beta 1. Nakade, O., Baylink, D.J., Lau, K.H. J. Bone Miner. Res. (1996) [Pubmed]
  15. Anti-catabolic effect of OP-1 in chronically compressed intervertebral discs. Chubinskaya, S., Kawakami, M., Rappoport, L., Matsumoto, T., Migita, N., Rueger, D.C. J. Orthop. Res. (2007) [Pubmed]
  16. Osteogenic protein-1 induced gene expression: evaluation in a posterolateral spinal pseudarthrosis model. White, A.P., Maak, T.G., Prince, D., Vaccaro, A.R., Albert, T.J., Hilibrand, A.S., Grauer, J.N. Spine (2006) [Pubmed]
  17. The effect of bone morphogenetic protein-7 on the expression of type I inositol 1,4,5-trisphosphate receptor in G-292 osteosarcoma cells and primary osteoblast cultures. Bradford, P.G., Maglich, J.M., Ponticelli, A.S., Kirkwood, K.L. Arch. Oral Biol. (2000) [Pubmed]
  18. BMP signals inhibit proliferation and in vivo tumor growth of androgen-insensitive prostate carcinoma cells. Miyazaki, H., Watabe, T., Kitamura, T., Miyazono, K. Oncogene (2004) [Pubmed]
  19. Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis. Lee-Hoeflich, S.T., Causing, C.G., Podkowa, M., Zhao, X., Wrana, J.L., Attisano, L. EMBO J. (2004) [Pubmed]
  20. Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis. Rebbapragada, A., Benchabane, H., Wrana, J.L., Celeste, A.J., Attisano, L. Mol. Cell. Biol. (2003) [Pubmed]
  21. Combined bone morphogenetic protein-2 and -7 gene transfer enhances osteoblastic differentiation and spine fusion in a rodent model. Zhu, W., Rawlins, B.A., Boachie-Adjei, O., Myers, E.R., Arimizu, J., Choi, E., Lieberman, J.R., Crystal, R.G., Hidaka, C. J. Bone Miner. Res. (2004) [Pubmed]
  22. Coordination of chondrocyte differentiation and joint formation by alpha5beta1 integrin in the developing appendicular skeleton. Garciadiego-Cázares, D., Rosales, C., Katoh, M., Chimal-Monroy, J. Development (2004) [Pubmed]
  23. Bone morphogenetic protein-7 (OP1) and transforming growth factor-beta1 modulate 1,25(OH)2-vitamin D3-induced differentiation of human osteoblasts. Eichner, A., Brock, J., Heldin, C.H., Souchelnytskyi, S. Exp. Cell Res. (2002) [Pubmed]
  24. BMP7 antagonizes TGF-beta -dependent fibrogenesis in mesangial cells. Wang, S., Hirschberg, R. Am. J. Physiol. Renal Physiol. (2003) [Pubmed]
  25. Expression of TGF-beta related Smad proteins in human epithelial skin tumors. Lange, D., Persson, U., Wollina, U., ten Dijke, P., Castelli, E., Heldin, C.H., Funa, K. Int. J. Oncol. (1999) [Pubmed]
  26. BMP7/ActRIIB regulates estrogen-dependent apoptosis: new biomarkers for environmental estrogens. Kusumegi, T., Tanaka, J., Kawano, M., Yonemoto, J., Tohyama, C., Sone, H. J. Biochem. Mol. Toxicol. (2004) [Pubmed]
  27. Osteogenic protein-1 promotes growth and maturation of chick sternal chondrocytes in serum-free cultures. Chen, P., Vukicevic, S., Sampath, T.K., Luyten, F.P. J. Cell. Sci. (1995) [Pubmed]
  28. Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily. Barbara, N.P., Wrana, J.L., Letarte, M. J. Biol. Chem. (1999) [Pubmed]
  29. The suppressive effect of myeloid elf-1-like factor (MEF) in osteogenic differentiation. Kim, Y.J., Kim, B.G., Lee, S.J., Lee, H.K., Lee, S.H., Ryoo, H.M., Cho, J.Y. J. Cell. Physiol. (2007) [Pubmed]
  30. Enhanced osteogenic promotion around dental implants with synthetic binding motif mimicking bone morphogenetic protein (BMP)-2. Seol, Y.J., Park, Y.J., Lee, S.C., Kim, K.H., Lee, J.Y., Kim, T.I., Lee, Y.M., Ku, Y., Rhyu, I.C., Han, S.B., Chung, C.P. Journal of biomedical materials research. Part A. (2006) [Pubmed]
  31. Expression of transferrin and vitamin D-binding protein genes in an osteogenic sarcoma cell line. Adrian, G.S., Yang, F.M., Graves, D.T., Buchanan, J.M., Bowman, B.H. Exp. Cell Res. (1990) [Pubmed]
  32. Enhancement of methotrexate nephrotoxicity after cisplatin therapy. Goren, M.P., Wright, R.K., Horowitz, M.E., Meyer, W.H. Cancer (1986) [Pubmed]
  33. Bone morphogenetic protein-7 expression and activity in the human adult normal kidney is predominantly localized to the distal nephron. Wetzel, P., Haag, J., Câmpean, V., Goldschmeding, R., Atalla, A., Amann, K., Aigner, T. Kidney Int. (2006) [Pubmed]
  34. Basic fibroblast growth factor inhibits the anabolic activity of insulin-like growth factor 1 and osteogenic protein 1 in adult human articular chondrocytes. Loeser, R.F., Chubinskaya, S., Pacione, C., Im, H.J. Arthritis Rheum. (2005) [Pubmed]
  35. Osteogenic differentiation of human mesenchymal stem cells is regulated by bone morphogenetic protein-6. Friedman, M.S., Long, M.W., Hankenson, K.D. J. Cell. Biochem. (2006) [Pubmed]
  36. Periodontal tissue regeneration by combined applications of recombinant human osteogenic protein-1 and bone morphogenetic protein-2. A pilot study in Chacma baboons (Papio ursinus). Ripamonti, U., Crooks, J., Petit, J.C., Rueger, D.C. Eur. J. Oral Sci. (2001) [Pubmed]
  37. Effects of osteogenic protein-1 (OP-1, BMP-7) on gene expression in cultured medial collateral ligament cells. Tsai, A.D., Yeh, L.C., Lee, J.C. J. Cell. Biochem. (2003) [Pubmed]
  38. Osteogenic differentiation induced by bone morphogenetic proteins can be suppressed by platelet-released supernatant in vitro. Gruber, R., Kandler, B., Fischer, M.B., Watzek, G. Clinical oral implants research. (2006) [Pubmed]
  39. Cloning and characterization of a human type II receptor for bone morphogenetic proteins. Rosenzweig, B.L., Imamura, T., Okadome, T., Cox, G.N., Yamashita, H., ten Dijke, P., Heldin, C.H., Miyazono, K. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  40. Osteogenic potential of five different recombinant human bone morphogenetic protein adenoviral vectors in the rat. Li, J.Z., Li, H., Sasaki, T., Holman, D., Beres, B., Dumont, R.J., Pittman, D.D., Hankins, G.R., Helm, G.A. Gene Ther. (2003) [Pubmed]
  41. Interaction of Ihh and BMP/Noggin signaling during cartilage differentiation. Pathi, S., Rutenberg, J.B., Johnson, R.L., Vortkamp, A. Dev. Biol. (1999) [Pubmed]
  42. Bone Morphogenetic Protein-7 Is an Antagonist of Transforming Growth Factor-{beta}2 in Human Trabecular Meshwork Cells. Fuchshofer, R., Yu, A.H., Welge-Lüssen, U., Tamm, E.R. Invest. Ophthalmol. Vis. Sci. (2007) [Pubmed]
  43. Mutual regulation of follicle-stimulating hormone signaling and bone morphogenetic protein system in human granulosa cells. Miyoshi, T., Otsuka, F., Suzuki, J., Takeda, M., Inagaki, K., Kano, Y., Otani, H., Mimura, Y., Ogura, T., Makino, H. Biol. Reprod. (2006) [Pubmed]
  44. A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7. Hahn, G.V., Cohen, R.B., Wozney, J.M., Levitz, C.L., Shore, E.M., Zasloff, M.A., Kaplan, F.S. Genomics (1992) [Pubmed]
  45. Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro. Sampath, T.K., Maliakal, J.C., Hauschka, P.V., Jones, W.K., Sasak, H., Tucker, R.F., White, K.H., Coughlin, J.E., Tucker, M.M., Pang, R.H. J. Biol. Chem. (1992) [Pubmed]
  46. Differential effect of activin A and BMP-7 on myofibroblast differentiation and the role of the Smad signaling pathway. You, L., Kruse, F.E. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
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