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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Weak promotion of C3H/10T1/2 cell transformation by repeated treatments with formaldehyde.

C3H/ 10T 1/2 cells were treated with N-methyl-N'-nitro-N-nitrosoguanidine and then repeatedly exposed to formaldehyde (0.1 to 2.0 micrograms/ml). Exposure of N-methyl-N'-nitro-N-nitrosoguanidine-initiated cultures to formaldehyde concentrations of 0.5 or 1.0 micrograms/ml in a variety of treatment regimens resulted in focus formation in up to 9% of the treated dishes. Transformed foci were observed in 2% or less of the cultures treated with N-methyl-N'-nitro-N-nitrosoguanidine or formaldehyde alone. Formaldehyde thus appears to be only a weak tumor promoter for C3H/ 10T 1/2 cell transformation.[1]

References

  1. Weak promotion of C3H/10T1/2 cell transformation by repeated treatments with formaldehyde. Frazelle, J.H., Abernethy, D.J., Boreiko, C.J. Cancer Res. (1983) [Pubmed]
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