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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The effect of dichloroacetate and hydroxypyruvate on the entry of 14C from [1-14C]alanine into urea in rat hepatocytes.

Entry of metabolic 14CO2 into urea is shown to be decreased by dichloroacetate although the production of 14CO2 is stimulated 2-fold. Hydroxypyruvate, a product of dichloroacetate metabolism, increases the incorporation of metabolic 14CO2 into urea. It is proposed that these effects result from changes in the cytoplasmic-mitochondrial pH gradient.[1]


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