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Chemical Compound Review

OH-pyr     3-hydroxy-2-oxo-propanoic acid

Synonyms: OH-pyruvate, AG-D-29676, AG-K-49558, CHEBI:30841, HMDB01352, ...
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Disease relevance of hydroxypyruvic acid


High impact information on hydroxypyruvic acid


Chemical compound and disease context of hydroxypyruvic acid


Biological context of hydroxypyruvic acid


Anatomical context of hydroxypyruvic acid


Associations of hydroxypyruvic acid with other chemical compounds


Gene context of hydroxypyruvic acid


Analytical, diagnostic and therapeutic context of hydroxypyruvic acid


  1. The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II. Cramer, S.D., Ferree, P.M., Lin, K., Milliner, D.S., Holmes, R.P. Hum. Mol. Genet. (1999) [Pubmed]
  2. Structural, kinetic, and renaturation properties of an induced hydroxypyruvate reductase from Pseudomonas acidovorans. Utting, J.M., Kohn, L.D. J. Biol. Chem. (1975) [Pubmed]
  3. Crystallization and preliminary diffraction studies of hydroxypyruvate reductase (D-glycerate dehydrogenase) from Hyphomicrobium methylovorum. Goldberg, J.D., Brick, P., Yoshida, T., Mitsunaga, T., Oshiro, T., Shimao, M., Izumi, Y. J. Mol. Biol. (1992) [Pubmed]
  4. Biochemical characterization of the 2-ketoacid reductases encoded by ycdW and yiaE genes in Escherichia coli. Nuñez, M.F., Pellicer, M.T., Badia, J., Aguilar, J., Baldoma, L. Biochem. J. (2001) [Pubmed]
  5. Inactivation of pyruvate decarboxylase by 3-hydroxypyruvate. Thomas, G., Diefenbach, R., Duggleby, R.G. Biochem. J. (1990) [Pubmed]
  6. Snapshot of a key intermediate in enzymatic thiamin catalysis: crystal structure of the alpha-carbanion of (alpha,beta-dihydroxyethyl)-thiamin diphosphate in the active site of transketolase from Saccharomyces cerevisiae. Fiedler, E., Thorell, S., Sandalova, T., Golbik, R., König, S., Schneider, G. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  7. D-lactate dehydrogenase is a member of the D-isomer-specific 2-hydroxyacid dehydrogenase family. Cloning, sequencing, and expression in Escherichia coli of the D-lactate dehydrogenase gene of Lactobacillus plantarum. Taguchi, H., Ohta, T. J. Biol. Chem. (1991) [Pubmed]
  8. Structural basis of substrate specificity in human glyoxylate reductase/hydroxypyruvate reductase. Booth, M.P., Conners, R., Rumsby, G., Brady, R.L. J. Mol. Biol. (2006) [Pubmed]
  9. The stereospecificity of sequential nicotinamide-adenine dinucleotide-dependent oxidoreductases in relation to the evolution of metabolic sequences. do Nascimento, K.H., Davies, D.D. Biochem. J. (1975) [Pubmed]
  10. Genetics of the serine cycle in Methylobacterium extorquens AM1: identification of sgaA and mtdA and sequences of sgaA, hprA, and mtdA. Chistoserdova, L.V., Lidstrom, M.E. J. Bacteriol. (1994) [Pubmed]
  11. 3-hydroxypyruvate substitutes for pyridoxine in serC mutants of Escherichia coli K-12. Shimizu, S., Dempsey, W.B. J. Bacteriol. (1978) [Pubmed]
  12. Light regulates alternative splicing of hydroxypyruvate reductase in pumpkin. Mano, S., Hayashi, M., Nishimura, M. Plant J. (1999) [Pubmed]
  13. Affinity labels for the anion-binding site in ovotransferrin. Bailey, C.T., Patch, M.G., Carrano, C.J. Biochemistry (1988) [Pubmed]
  14. Enzymatic synthesis and inhibitory characteristics of tartronate semialdehyde phosphate. Weiss, P.M., Boerner, R.J., Cleland, W.W. Biochemistry (1989) [Pubmed]
  15. Purification and characterization of hydroxypyruvate reductase from the facultative methylotroph Methylobacterium extorquens AM1. Chistoserdova, L.V., Lidstrom, M.E. J. Bacteriol. (1991) [Pubmed]
  16. Pumpkin hydroxypyruvate reductases with and without a putative C-terminal signal for targeting to microbodies may be produced by alternative splicing. Hayashi, M., Tsugeki, R., Kondo, M., Mori, H., Nishimura, M. Plant Mol. Biol. (1996) [Pubmed]
  17. Hydroxypyruvate as a gluconeogenic substrate in rat hepatocytes. Williamson, D.H., Ellington, E.V. Biochem. J. (1975) [Pubmed]
  18. Alternative oxidase in durum wheat mitochondria. Activation by pyruvate, hydroxypyruvate and glyoxylate and physiological role. Pastore, D., Trono, D., Laus, M.N., Di Fonzo, N., Passarella, S. Plant Cell Physiol. (2001) [Pubmed]
  19. Protein organization in the matrix of leaf peroxisomes. A multi-enzyme complex involved in photorespiratory metabolism. Heupel, R., Heldt, H.W. Eur. J. Biochem. (1994) [Pubmed]
  20. Hepatic oxalate production: the role of hydroxypyruvate. Rofe, A.M., James, H.M., Bais, R., Conyers, R.A. Biochem. Med. Metab. Biol. (1986) [Pubmed]
  21. Oxalate as a potent and selective inhibitor of spinach (Spinacia oleracea) leaf NADPH-dependent hydroxypyruvate reductase. Kleczkowski, L.A., Randall, D.D., Edwards, G.E. Biochem. J. (1991) [Pubmed]
  22. Reaction of serine-glyoxylate aminotransferase with the alternative substrate ketomalonate indicates rate-limiting protonation of a quinonoid intermediate. Karsten, W.E., Ohshiro, T., Izumi, Y., Cook, P.F. Biochemistry (2005) [Pubmed]
  23. The effect of dichloroacetate and hydroxypyruvate on the entry of 14C from [1-14C]alanine into urea in rat hepatocytes. Hems, R. FEBS Lett. (1983) [Pubmed]
  24. Transcriptional regulation of hydroxypyruvate reductase gene expression by cytokinin in etiolated pumpkin cotyledons. Andersen, B.R., Jin, G., Chen, R., Ertl, J.R., Chen, C.M. Planta (1996) [Pubmed]
  25. Mitochondrial compartmentation of metabolic CO2 resulting from its site of origin in relation to urea synthesis. Hems, R. FEBS Lett. (1984) [Pubmed]
  26. Structure and mechanism of a sub-family of enzymes related to N-acetylneuraminate lyase. Lawrence, M.C., Barbosa, J.A., Smith, B.J., Hall, N.E., Pilling, P.A., Ooi, H.C., Marcuccio, S.M. J. Mol. Biol. (1997) [Pubmed]
  27. A new family of 2-hydroxyacid dehydrogenases. Grant, G.A. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  28. Purification and characterization of a novel NADPH(NADH)-dependent hydroxypyruvate reductase from spinach leaves. Comparison of immunological properties of leaf hydroxypyruvate reductases. Kleczkowski, L.A., Randall, D.D. Biochem. J. (1988) [Pubmed]
  29. Cloning, mutagenesis, and physiological effect of a hydroxypyruvate reductase gene from Methylobacterium extorquens AM1. Chistoserdova, L.V., Lidstrom, M.E. J. Bacteriol. (1992) [Pubmed]
  30. Isolation, characterization and sequence analysis of a full-length cDNA clone encoding NADH-dependent hydroxypyruvate reductase from cucumber. Greenler, J.M., Sloan, J.S., Schwartz, B.W., Becker, W.M. Plant Mol. Biol. (1989) [Pubmed]
  31. Immunological characterization of serine-glyoxylate aminotransferase and hydroxypyruvate reductase from a methylotrophic bacterium, Hyphomicrobium methylovorum GM2. Hagishita, T., Yoshida, T., Izumi, Y., Mitsunaga, T. FEMS Microbiol. Lett. (1996) [Pubmed]
  32. Synthesis with good enantiomeric excess of both enantiomers of alpha-ketols and acetolactates by two thiamin diphosphate-dependent decarboxylases. Baykal, A., Chakraborty, S., Dodoo, A., Jordan, F. Bioorg. Chem. (2006) [Pubmed]
  33. Hyperoxaluria in L-glyceric aciduria: possible nonenzymic mechanism. Raghavan, K.G., Richardson, K.E. Biochemical medicine. (1983) [Pubmed]
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