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Chemical Compound Review

AC1OAGHK     3,3-dichloropropanoate

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Disease relevance of Dichloroacetate


Psychiatry related information on Dichloroacetate


High impact information on Dichloroacetate


Chemical compound and disease context of Dichloroacetate


Biological context of Dichloroacetate


Anatomical context of Dichloroacetate


Associations of Dichloroacetate with other chemical compounds


Gene context of Dichloroacetate


Analytical, diagnostic and therapeutic context of Dichloroacetate


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  16. Effect of dichloroacetate on the exercise performance of patients with heart failure. Wilson, J.R., Mancini, D.M., Ferraro, N., Egler, J. J. Am. Coll. Cardiol. (1988) [Pubmed]
  17. Acute effects of dichloroacetate in the depancreatized dog: glucose synthesis and turnover. Searle, G.L., Felts, J.M., Shakelford, R. Diabetologia (1982) [Pubmed]
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  19. Abnormal activation of pyruvate dehydrogenase in Leigh disease fibroblasts. Sorbi, S., Blass, J.P. Neurology (1982) [Pubmed]
  20. Dichloroacetate stabilizes the mutant E1alpha subunit in pyruvate dehydrogenase deficiency. Morten, K.J., Beattie, P., Brown, G.K., Matthews, P.M. Neurology (1999) [Pubmed]
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  22. Pyruvate dehydrogenase influences postischemic heart function. Lewandowski, E.D., White, L.T. Circulation (1995) [Pubmed]
  23. Cardiac efficiency is improved after ischemia by altering both the source and fate of protons. Liu, B., Clanachan, A.S., Schulz, R., Lopaschuk, G.D. Circ. Res. (1996) [Pubmed]
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  25. The kinetics, substrate, and inhibitor specificity of the monocarboxylate (lactate) transporter of rat liver cells determined using the fluorescent intracellular pH indicator, 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein. Jackson, V.N., Halestrap, A.P. J. Biol. Chem. (1996) [Pubmed]
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  28. Increased expression of c-myc and c-Ha-ras in dichloroacetate and trichloroacetate-induced liver tumors in B6C3F1 mice. Nelson, M.A., Sanchez, I.M., Bull, R.J., Sylvester, S.R. Toxicology (1990) [Pubmed]
  29. A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Bonnet, S., Archer, S.L., Allalunis-Turner, J., Haromy, A., Beaulieu, C., Thompson, R., Lee, C.T., Lopaschuk, G.D., Puttagunta, L., Bonnet, S., Harry, G., Hashimoto, K., Porter, C.J., Andrade, M.A., Thebaud, B., Michelakis, E.D. Cancer Cell (2007) [Pubmed]
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  31. Metabolic effects and pharmacokinetics of intravenously administered dichloroacetate in humans. Wells, P.G., Moore, G.W., Rabin, D., Wilkinson, G.R., Oates, J.A., Stacpoole, P.W. Diabetologia (1980) [Pubmed]
  32. Trapping and identification of the dichloroacetate radical from the reductive dehalogenation of trichloroacetate by mouse and rat liver microsomes. Merdink, J.L., Bull, R.J., Schultz, I.R. Free Radic. Biol. Med. (2000) [Pubmed]
  33. Age-related differences in the effect of dichloroacetate on postischemic lactate and acid clearance measured in vivo using magnetic resonance spectroscopy and microdialysis. Corbett, R., Laptook, A., Gee, J., Garcia, D., Silmon, S., Tollefsbol, G. J. Neurochem. (1998) [Pubmed]
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