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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Clinical and laboratory features of canine lupus syndromes.

Determination of the specificities of antinuclear antibodies in the sera of 20 dogs presenting with symptoms of a lupus-like syndrome permitted their separation into 2 groups. The first group of 14 dogs all had antibody activity to DNA-histone antigen(s), and 4 of them also had antibodies to native DNA (nDNA). The Farr test with standard buffer was found to be unsatisfactory for the measurement of anti-nDNA antibodies in dog sera due to a high incidence of false positive reactions; these could be eliminated by the inclusion of sodium dodecyl sulfate in the buffer system. The second group of 6 dogs was characterized by the presence of antibodies to extractable nuclear antigen. In every serum tested diseased dogs had a diminished level of circulating thymic factor as compared to controls of the same age, suggesting that a diminution of suppressor T cells may be an etiologic factor.[1]


  1. Clinical and laboratory features of canine lupus syndromes. Monier, J.C., Dardenne, M., Rigal, D., Costa, O., Fournel, C., Lapras, M. Arthritis Rheum. (1980) [Pubmed]
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