Genetic locus, distant from ptsM, affecting enzyme IIA/IIB function in Escherichia coli K-12.
Most strains of Escherichia coli K-12 are unable to use the enzyme IIA/IIB (enzyme IIMan) complex of the phosphoenolpyruvate:sugar phosphotransferase system ( PTS) in anaerobic growth and therefore cannot utilize glucosamine anaerobically. Introduction into these strains of a ptsG mutation, which eliminates activity of the enzyme IIIGlc/IIB' complex of the PTS, resulted in inability to grow anaerobically on glucose and mannose. Derivative strains able to grow anaerobically on glucosamine had mutations at a locus close to man, the gene coding for phosphomannose isomerase, and had higher enzyme IIA/IIB activities during anaerobic growth than did the parental strain. These results establish a locus affecting function of enzyme IIA/IIB that maps distant from ptsM, the probable structural gene for enzyme IIB.[1]References
- Genetic locus, distant from ptsM, affecting enzyme IIA/IIB function in Escherichia coli K-12. Roehl, R.A., Vinopal, R.T. J. Bacteriol. (1980) [Pubmed]
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