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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Decrease of tumor growth in mice after intravenous thymosin-treated bone marrow cell injection.

The effect of iv injection in C57BL/6 mice of 3X10(7) bone marrow cells preincubated in either thymosin fraction V or thymosin alpha-1 was evaluated on the growth of a 3-methylcholanthrene-induced transplantable tumor in a syngeneic system. The effect was then compared to that elicited by theophylline or levamisole, which both demonstrated thymosin-like action in vitro. The results showed significantly retarded tumor growth (P less than 0.001) and prolonged survival time (P less than 0.001) when thymosin fraction V was used. The same results were obtained with thymosin alpha-1 with use of the same protocol but only one-twentieth of the concentration of fraction V. Theophylline and levamisole demonstrated no antitumor effect.[1]

References

  1. Decrease of tumor growth in mice after intravenous thymosin-treated bone marrow cell injection. Cupissol, D., Rey, A., Goldstein, A.L., Serrou, B. J. Natl. Cancer Inst. (1982) [Pubmed]
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