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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Impaired clot retraction in thrombocytopenia due to methyldopa.

We have described a case of thrombocytopenic purpura caused by methyldopa. A methyldopa-dependent antiplatelet antibody as the mechanism of the patient's thrombopenia was suggested by a positive clot retraction inhibition test. This simple in vitro test should be done more often in suspected cases of drug-induced thrombocytopenia.[1]


  1. Impaired clot retraction in thrombocytopenia due to methyldopa. Polk, O.D., Kletter, G.G., Smith, J., Castro, O. South. Med. J. (1982) [Pubmed]
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