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MeSH Review

Clot Retraction

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Disease relevance of Clot Retraction


High impact information on Clot Retraction


Biological context of Clot Retraction


Anatomical context of Clot Retraction


Associations of Clot Retraction with chemical compounds

  • The contribution of the three hypothesized integrin-binding sites in fibrinogen to platelet-mediated clot retraction [16].
  • Other tests of platelet function including clot retraction, platelet factor 3 availability, and collagen-induced or epinephrine-induced aggregation remained normal during the administration of these drugs [17].
  • These effects were selective because fibrin clot retraction, a response also dependent on alphaIIbbeta3 and actin contractility, was unaffected by C3, as was the content of F-actin in resting or agonist-stimulated platelets [18].
  • Propanolol blocked the release of 14C-serotonin from platelets, inhibited platelet adhesion to collagen, and interfered with clot retraction [19].
  • This relaxation of clot retraction was observed in both thrombin and ionophore A23187-stimulated platelets [20].

Gene context of Clot Retraction

  • In addition, D3 also inhibited whole blood clot retraction, in contrast to AP3 and C3, suggesting that conformational constraints on alphaIIbbeta3 by D3 binding not only influenced the CD9 complex but also affected alphaIIbbeta3 post receptor occupancy events [21].
  • Inhibition of clot lysis and decreased binding of tissue-type plasminogen activator as a consequence of clot retraction [22].
  • These data suggest that platelets inhibit clot lysis at therapeutic concentrations of t-PA as a consequence of clot retraction and decreased access of fibrinolytic proteins [22].
  • Antibodies to GPIIb alpha (300-312) inhibit Fg binding, clot retraction, and platelet adhesion to multiple ligands [23].
  • These experiments define requirements for alpha IIb beta 3-mediating clot retraction, establish the capacity of alpha v beta 3 to mediate this process, and suggest differing functional roles of the alpha v and alpha IIb cytoplasmic domains [2].

Analytical, diagnostic and therapeutic context of Clot Retraction


  1. PTP-1B is an essential positive regulator of platelet integrin signaling. Arias-Salgado, E.G., Haj, F., Dubois, C., Moran, B., Kasirer-Friede, A., Furie, B.C., Furie, B., Neel, B.G., Shattil, S.J. J. Cell Biol. (2005) [Pubmed]
  2. Beta 3 integrin-mediated fibrin clot retraction by nucleated cells: differing behavior of alpha IIb beta 3 and alpha v beta 3. Chen, Y.P., O'Toole, T.E., Leong, L., Liu, B.Q., Diaz-Gonzalez, F., Ginsberg, M.H. Blood (1995) [Pubmed]
  3. Platelet function in chronic leukemias. Naresh, K.N., Sivasankaran, P., Veliath, A.J. Indian journal of cancer. (1992) [Pubmed]
  4. Impaired clot retraction in thrombocytopenia due to methyldopa. Polk, O.D., Kletter, G.G., Smith, J., Castro, O. South. Med. J. (1982) [Pubmed]
  5. Platelet function in acute leukemias. Naresh, K.N., Sivasankaran, P., Veliath, A.J. The Journal of the Association of Physicians of India. (1993) [Pubmed]
  6. Functionally thrombasthenic state in normal platelets following the administration of ticlopidine. Di Minno, G., Cerbone, A.M., Mattioli, P.L., Turco, S., Iovine, C., Mancini, M. J. Clin. Invest. (1985) [Pubmed]
  7. Impaired platelet aggregation and sustained bleeding in mice lacking the fibrinogen motif bound by integrin alpha IIb beta 3. Holmbäck, K., Danton, M.J., Suh, T.T., Daugherty, C.C., Degen, J.L. EMBO J. (1996) [Pubmed]
  8. A naturally occurring Tyr143His alpha IIb mutation abolishes alpha IIb beta 3 function for soluble ligands but retains its ability for mediating cell adhesion and clot retraction: comparison with other mutations causing ligand-binding defects. Kiyoi, T., Tomiyama, Y., Honda, S., Tadokoro, S., Arai, M., Kashiwagi, H., Kosugi, S., Kato, H., Kurata, Y., Matsuzawa, Y. Blood (2003) [Pubmed]
  9. Active GPIIb-IIIa conformations that link ligand interaction with cytoskeletal reorganization. Mondoro, T.H., White, M.M., Jennings, L.K. Blood (2000) [Pubmed]
  10. The role of putative fibrinogen Aalpha-, Bbeta-, and GammaA-chain integrin binding sites in endothelial cell-mediated clot retraction. Smith, R.A., Mosesson, M.W., Rooney, M.M., Lord, S.T., Daniels, A.U., Gartner, T.K. J. Biol. Chem. (1997) [Pubmed]
  11. Inhibition of platelet aggregation by a new agent, Ticlopidine. Ashida, S.I., Abiko, Y. Thromb. Haemost. (1979) [Pubmed]
  12. Comparison of fibrin clot retraction with other transformation parameters after hydridization of normal and established cell lines. Curatolo, L., Azzarone, B., Fally-Crépin, C., Morasca, L., Macieira-Coelho, A. Int. J. Cancer (1983) [Pubmed]
  13. Fibrin clot retraction by human platelets correlates with alpha(IIb)beta(3) integrin-dependent protein tyrosine dephosphorylation. Osdoit, S., Rosa, J.P. J. Biol. Chem. (2001) [Pubmed]
  14. Ionophore a 23187: some effects on platelet aggregation and clot retraction. Bottecchia, D., Fantin, G., Gruppo, F., Nassuato, G. Haemostasis (1976) [Pubmed]
  15. Possible mechanisms of epinephrine actions in quin-2-loaded platelets refractory to arachidonic acid. Rao, G.H., Gerrard, J.M., Murthy, M., White, J.G. Biochem. Med. Metab. Biol. (1993) [Pubmed]
  16. The contribution of the three hypothesized integrin-binding sites in fibrinogen to platelet-mediated clot retraction. Rooney, M.M., Farrell, D.H., van Hemel, B.M., de Groot, P.G., Lord, S.T. Blood (1998) [Pubmed]
  17. Defective platelet function following the administration of penicillin compounds. Brown, C.H., Bradshaw, M.J., Natelson, E.A., Alfrey, C.P., Williams, T.W. Blood (1976) [Pubmed]
  18. RhoA and the function of platelet integrin alphaIIbbeta3. Leng, L., Kashiwagi, H., Ren, X.D., Shattil, S.J. Blood (1998) [Pubmed]
  19. Effect of propranolol on platelet function. Weksler, B.B., Gillick, M., Pink, J. Blood (1977) [Pubmed]
  20. Calpain cleavage of focal adhesion proteins regulates the cytoskeletal attachment of integrin alphaIIbbeta3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin clots. Schoenwaelder, S.M., Yuan, Y., Cooray, P., Salem, H.H., Jackson, S.P. J. Biol. Chem. (1997) [Pubmed]
  21. A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states. Longhurst, C.M., White, M.M., Wilkinson, D.A., Jennings, L.K. Eur. J. Biochem. (1999) [Pubmed]
  22. Inhibition of clot lysis and decreased binding of tissue-type plasminogen activator as a consequence of clot retraction. Kunitada, S., FitzGerald, G.A., Fitzgerald, D.J. Blood (1992) [Pubmed]
  23. Antibodies to GPIIb alpha (300-312) inhibit Fg binding, clot retraction, and platelet adhesion to multiple ligands. Taylor, D.B., Derrick, J.M., Gartner, T.K. Proc. Soc. Exp. Biol. Med. (1994) [Pubmed]
  24. Force monitoring of clot retraction during DDAVP therapy for the qualitative platelet disorder of uraemia: report of a case. Carr, M.E., Zekert, S.L. Blood Coagul. Fibrinolysis (1991) [Pubmed]
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