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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The effect of activated dimethicone and a proprietary antacid preparation containing this agent on the absorption of phenytoin.

1 The bioavailabilty of phenytoin sodium (Epanutin both alone and in combination with activated dimethicone and Asilone (a proprietary antacid preparation containing activated dimethicone) was examined in six healthy male volunteers. 2 The bioavailability of phenytoin when given concomitantly with Asilone was decreased in five of six volunteer subjects (by greater than 30% in three subjects) although this decrease was not shown to be statistically significant. 3 Dimethicone, which has been shown to decrease phenytoin absorption in vitro did not affect phenytoin bioavailability in vivo. 4 It is recommended that when treating patients stabilised on phenytoin one should exercise caution with concomitant phenytoin and antacid therapy to guard against possible changed drug absorption.[1]

References

  1. The effect of activated dimethicone and a proprietary antacid preparation containing this agent on the absorption of phenytoin. McElnay, J.C., Uprichard, G., Collier, P.S. British journal of clinical pharmacology. (1982) [Pubmed]
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