The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

HMDSO     trimethyl-trimethylsilyloxy- silane

Synonyms: Fluka AG, SWS-F 221, CCRIS 1325, AG-C-85842, ACMC-2098wd, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of DIMETHICONE

  • Neither corn oil used as a control nor 1000-centistoke or 12,500-centistoke dimethylpolysiloxane induced plasmacytomas in these mice [1].
  • A case of giant retinal tear treated by injection with dimethicone 350 (medical fluid silicone) was observed for six years before enucleation [2].
  • In the present study, two histologically-distinct cases of granulomatous lymphadenitis induced by dimethylpolysiloxane (silicone polymer) implants were studied [3].
  • Activated dimeticone, for treatment of colic and flatulence, was given to 16% of babies and gripe water was used by 13% [4].
  • There was no evidence from this study that the bile acid binding and anti-foaming properties of hydrotalcite/dimethicone suspension were of any benefit in the treatment of patients with symptomatic gastritis [5].

High impact information on DIMETHICONE

  • The addition of EGF to mesangial cells cultured on either glass or dimethylpolysiloxane substratum induced reproducible cell contraction [6].
  • The resulting monomeric silanol species were then capped with trimethylsilyl groups, extracted into hexamethyldisiloxane, and analyzed by gas chromatography [7].
  • Therefore, it was concluded that the microemboli were droplets of antifoam agent, the refractile particles corresponding to the particulate silica component and the vacuoles corresponding to the dimethylpolysiloxane liquid component [8].
  • Further NR measurements were conducted with the AA and HMDSO films in contact with water at neutral pH [9].
  • To minimize the interfering effect of aqueous electrolytes on the impedance responses of the ttb-CuPc film itself, Au/Cr interdigitated planar electrodes bearing ttb-CuPc thin films were protected with hydrophobic gas-permeable membranes, namely thermally evaporated calixarene or plasma polymerized hexamethyldisiloxane films [10].

Chemical compound and disease context of DIMETHICONE


Biological context of DIMETHICONE


Anatomical context of DIMETHICONE


Associations of DIMETHICONE with other chemical compounds


Gene context of DIMETHICONE

  • The subjacent bone was sectioned and ashed at 600 degrees C. Ash and plasma were analyzed for F with the electrode following hexamethyldisiloxane-facilitated diffusion [23].

Analytical, diagnostic and therapeutic context of DIMETHICONE


  1. Induction of plasmacytomas with silicone gel in genetically susceptible strains of mice. Potter, M., Morrison, S., Wiener, F., Zhang, X.K., Miller, F.W. J. Natl. Cancer Inst. (1994) [Pubmed]
  2. Ocular findings six years after intravitreal silicone injection. Sugar, H.S., Okamura, I.D. Arch. Ophthalmol. (1976) [Pubmed]
  3. Silicone granulomatous lymphadenopathy and siliconomas of the breast. Vaamonde, R., Cabrera, J.M., Vaamonde-Martín, R.J., Jimena, I., Marcos Martín, J. Histol. Histopathol. (1997) [Pubmed]
  4. Medication administered to children from 0 to 7.5 years in the Avon Longitudinal Study of Parents and Children (ALSPAC). Headley, J., Northstone, K. Eur. J. Clin. Pharmacol. (2007) [Pubmed]
  5. Double-blind clinical, endoscopic and histological comparison of hydrotalcite/dimethicone suspension and magnesium hydroxide/aluminum hydroxide suspension in the treatment of symptomatic gastritis. Cobden, I., McMahon, M.J., Dixon, M.F., Axon, A.T. Pharmatherapeutica. (1981) [Pubmed]
  6. Evidence for glomerular actions of epidermal growth factor in the rat. Harris, R.C., Hoover, R.L., Jacobson, H.R., Badr, K.F. J. Clin. Invest. (1988) [Pubmed]
  7. Methods for detecting silicones in biological matrixes. Kennan, J.J., Breen, L.L., Lane, T.H., Taylor, R.B. Anal. Chem. (1999) [Pubmed]
  8. Microemboli observed in deaths following cardiopulmonary bypass surgery: silicone antifoam agents and polyvinyl chloride tubing as sources of emboli. Orenstein, J.M., Sato, N., Aaron, B., Buchholz, B., Bloom, S. Hum. Pathol. (1982) [Pubmed]
  9. X-ray and neutron reflectometry study of glow-discharge plasma polymer films. Nelson, A., Muir, B.W., Oldham, J., Fong, C., McLean, K.M., Hartley, P.G., Oiseth, S.K., James, M. Langmuir : the ACS journal of surfaces and colloids. (2006) [Pubmed]
  10. An approach to conductometric immunosensor based on phthalocyanine thin film. Sergeyeva, T.A., Lavrik, N.V., Rachkov, A.E., Kazantseva, Z.I., El'skaya, A.V. Biosensors & bioelectronics. (1998) [Pubmed]
  11. The effect of activated dimethicone and a proprietary antacid preparation containing this agent on the absorption of phenytoin. McElnay, J.C., Uprichard, G., Collier, P.S. British journal of clinical pharmacology. (1982) [Pubmed]
  12. Closed-chamber inhalation pharmacokinetic studies with hexamethyldisiloxane in the rat. Dobrev, I.D., Reddy, M.B., Plotzke, K.P., Varaprath, S., McNett, D.A., Durham, J., Andersen, M.E. Inhalation toxicology. (2003) [Pubmed]
  13. Effect of dimethicone (polysilane gel) on the stereoselective pharmacokinetics of ketoprofen. Presle, N., Lapicque, F., Gillet, P., Herrmann, M.A., Bannwarth, B., Netter, P. Eur. J. Clin. Pharmacol. (1998) [Pubmed]
  14. Lindholm blood coagulation test values of some glow-discharge polymer surfaces. Yasuda, H., Bumgarner, M.O., Mason, R.G. Biomaterials, medical devices, and artificial organs. (1976) [Pubmed]
  15. Surface characterization and ex vivo blood compatibility study of plasma-modified small diameter tubing: effect of sulphur dioxide and hexamethyldisiloxane plasmas. Lin, J.C., Cooper, S.L. Biomaterials (1995) [Pubmed]
  16. Retinal vascular occlusions in open heart surgery. Williams, I.M. The British journal of ophthalmology. (1975) [Pubmed]
  17. Fate of 14C-labelled dimethylpolysiloxane (silicone oil) in a root canal filling material embedded in rat subcutaneous tissues. Kawakami, T., Nakakamura, C., Hasegawa, H., Eda, S. Dental materials : official publication of the Academy of Dental Materials. (1987) [Pubmed]
  18. cAMP levels in reactive tissues around dimethylpolysiloxane solid implants. Faga, A., Merlino, M. Plast. Reconstr. Surg. (1985) [Pubmed]
  19. Dimethylpolysiloxane as an adjuvant in double-contrast barium enema. Virkki, R., Mäkelä, P., Kormano, M. European journal of radiology. (1981) [Pubmed]
  20. Progesterone administration by nasal spray in menopausal women: comparison between two different spray formulations. Cicinelli, E., Savino, F., Cagnazzo, I., Scorcia, P., Galantino, P. Gynecol. Endocrinol. (1992) [Pubmed]
  21. Treatment of head louse infestation with 4% dimeticone lotion: randomised controlled equivalence trial. Burgess, I.F., Brown, C.M., Lee, P.N. BMJ (2005) [Pubmed]
  22. In vitro experiments on chloroquine and pyrimethamine absorption in the presence of antacid constituents or kaolin. McElnay, J.C., Mukhtar, H.A., D'Arcy, P.F., Temple, D.J. The Journal of tropical medicine and hygiene. (1982) [Pubmed]
  23. Bone surface and whole bone as biomarkers for acute fluoride exposure. Buzalaf, M.A., Caroselli, E.E., de Carvalho, J.G., de Oliveira, R.C., da Silva Cardoso, V.E., Whitford, G.M. Journal of analytical toxicology. (2005) [Pubmed]
  24. Capillary electrophoresis of sialic acid-containing glycoprotein. Effect of the heterogeneity of carbohydrate chains on glycoform separation using an alpha1-acid glycoprotein as a model. Kakehi, K., Kinoshita, M., Kawakami, D., Tanaka, J., Sei, K., Endo, K., Oda, Y., Iwaki, M., Masuko, T. Anal. Chem. (2001) [Pubmed]
  25. Electrically heated, air-cooled thermal modulator and at-column heating for comprehensive two-dimensional gas chromatography. Libardoni, M., Waite, J.H., Sacks, R. Anal. Chem. (2005) [Pubmed]
  26. Novel 1H NMR approach to quantitative tissue oximetry using hexamethyldisiloxane. Kodibagkar, V.D., Cui, W., Merritt, M.E., Mason, R.P. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (2006) [Pubmed]
  27. Pre-medication with pronase reduces artefacts during endoscopic ultrasonography. Sakai, N., Tatsuta, M., Iishi, H., Nakaizumi, A. Aliment. Pharmacol. Ther. (2003) [Pubmed]
  28. Improved quality of anorectal endoluminal ultrasonography using emulsion of dimethicone. de la Portilla, F., Ynfante, I., Fernández, A., Bejarano, D., Carranza, G. Dis. Colon Rectum (2003) [Pubmed]
WikiGenes - Universities