Genetic analysis of bacteriophage T4 transducing bacteriophages.
Mutations in the genes for nuclear disruption ( ndd), endonuclease IV (denB), and the D1 region of the T4 genome are essential for converting bacteriophage T4 into a generalized transducing phage. These mutations gave rise to a very low frequency of transduction, about 10(-8) per infected bacterium. The addition of an rII mutation raised the transduction frequency about 20-fold. An additional 100-fold increase in the transduction frequency was observed with mutations in genes 42, 56, and alc. High-frequency generalized transduction by T4 results from the cumulative effect of these mutations.[1]References
- Genetic analysis of bacteriophage T4 transducing bacteriophages. Young, K.K., Edlin, G.J., Wilson, G.G. J. Virol. (1982) [Pubmed]
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