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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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In vivo pharmacokinetics of triazinate in L-1210 and W-256 cells.

A pharmacokinetic model for triazinate uptake in L-1210 cells in mice and W-256 cells in rats was developed to describe the observed concentration profiles with time in these cells following a 36 mg/m2 ip injection. The L-1210 cell permeability to triazinate was found to the approximately or 15 times smaller compared with W-256 cells. Similarly, the partition coefficient for L-1210 cells was calculated to be approximately or 175 times smaller than for W-256 cells. Cell membrane permeability appears to be the key parameter determining the drug transport at a short time after injection.[1]

References

  1. In vivo pharmacokinetics of triazinate in L-1210 and W-256 cells. Townsend, J.G., Jain, R.K., Cashmore, A.R. Journal of pharmaceutical sciences. (1982) [Pubmed]
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