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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Azathioprine teratogenicity: review of the literature and case report.

An infant born with preaxial polydactyly to a mother taking azathioprine throughout pregnancy is described. Experimental studies in animals reveal a teratogenic role for azathioprine and its main metabolite, 6-mercaptopurine. The skeletal system appears to be the primary tissue target for such action of these drugs. Although no direct cause-effect relationship can be established from the single case presented, the similarity of this anomaly to experimental azathioprine teratogenesis suggests the necessity for further surveillance.[1]


  1. Azathioprine teratogenicity: review of the literature and case report. Williamson, R.A., Karp, L.E. Obstetrics and gynecology. (1981) [Pubmed]
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