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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Plasma MHPG in rapid cyclers and healthy twins.

We measured plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) in 13 pairs of healthy drug-free monozygotic twins. High concordance for both free and conjugated MHPG suggests that plasma levels of the metabolite may reflect a heritable biological trait. In two drug-free rapidly cycling patients studied longitudinally, plasma MHPG levels reflected alterations in psychiatric state; they were significantly higher during mania than during depression. Although largely reflecting peripheral sources, plasma MHPG level as a global index of noradrenergic function may complement urinary MHPG excretion as a probe for diagnostic subgroups or pharmacologic responsiveness in psychiatric research.[1]

References

  1. Plasma MHPG in rapid cyclers and healthy twins. Jimerson, D.C., Nurnberger, J.I., Post, R.M., Gershon, E.S., Kopin, I.J. Arch. Gen. Psychiatry (1981) [Pubmed]
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