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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Tumor imaging with radioactive metal chelates conjugated to monoclonal antibodies.

High-resolution gamma camera images of mouse erythroid tumors were obtained by use of leukemia cell-specific monoclonal antibodies labeled with bifunctional radioactive metal chelates. Small tumors (200 to 300 milligrams) were visible without subtraction or enhancement 1 to 5 hours after injection of antibody. Chelate-derivitized monoclonal antibodies permit targeting of a broad spectrum of radioisotopes, including those that are optimum for agamma for gamma camera imaging or positron tomography, as well as those that are tumoricidal.[1]


  1. Tumor imaging with radioactive metal chelates conjugated to monoclonal antibodies. Scheinberg, D.A., Strand, M., Gansow, O.A. Science (1982) [Pubmed]
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