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MeSH Review

Gamma Cameras

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Disease relevance of Gamma Cameras


Psychiatry related information on Gamma Cameras


High impact information on Gamma Cameras

  • High-resolution gamma camera images of mouse erythroid tumors were obtained by use of leukemia cell-specific monoclonal antibodies labeled with bifunctional radioactive metal chelates [7].
  • The technique employs measurement with a computer-linked gamma camera of the activity ratio in an area of the right lung compared with the same-sized area in the heart at 20 minutes and three hours following intravenous injection of technetium Tc 99m albumin [8].
  • It is not clear which of the three methods used reflects better the extent or clinical significance of the amyloid deposits but in vivo localization of radiolabeled SAP, detectable and quantifiable by gamma camera imaging, is apparently extremely sensitive [9].
  • Finally, a scintillation camera was employed to visually and quantitatively detect 125I-hydroxybenzylpindolol displacement from the lung during intravenous propranolol administration in the living animal [10].
  • 123I-labelled tyr-3-octreotide (tyr-3-SMS 201-995, a synthetic derivative of somatostatin) was used to localise such tumours in vivo with a gamma-camera [11].

Chemical compound and disease context of Gamma Cameras


Biological context of Gamma Cameras


Anatomical context of Gamma Cameras

  • Over the next 4-hour study period, myocardial Tc-MIBI activities were continuously monitored in both the left anterior descending (LAD) (normal) and left circumflex (LCx) (ischemic) coronary artery (ischemic) zones using miniature cadmium telluride radiation detectors and serial gamma camera images were acquired when necessary [22].
  • At 8 and 32 hours after saphenous vein bypass graft surgery in six dogs, in vivo images of the graft were obtained with a gamma camera after intravenous injection, 2 hours postoperatively of autologous platelets labeled with indium-111 [23].
  • M195 was trace-labeled with iodine-131 (131I) to allow detailed pharmacokinetic and dosimetric studies by serial sampling of blood and bone marrow and whole-body gamma-camera imaging [24].
  • From a series of gamma-camera images, it was found that lithium increased 131I retention in 24 of 31 metastatic lesions and in 6 of 7 thyroid remnants [25].
  • Transmission-emission scanning of the thorax with a flood source of technetium-99m (99mTc), autologous 99mTc labelled red blood cells, and diethylenetriaminepenta-acetic acid (99mTc DTPA) allows measurement of thoracic tissue thickness and blood and interstitial volume per pixel of the gamma camera image [26].

Associations of Gamma Cameras with chemical compounds

  • Clearance of excessive bronchial secretions labelled with inhaled radioactive polystyrene particles has been directly measured with a gamma-camera linked to a computer [27].
  • The subjects ingested an isosmotic lactulose solution containing 99mtechnetium-diethylenetriaminepentaacetic acid (Sn) and then remained supine under a large field of view gamma-camera that interfaced with a computer system [28].
  • INTERVENTIONS: Adrenal scintiscans done using 1 mCi of NP-59 intravenously, and gamma camera imaging 5 to 7 days later [29].
  • Gamma camera images of the heart were obtained after each injection of thallium [30].
  • Acute platelet deposition was continuously measured during 1 hour using gamma camera imaging of platelets labeled with indium-111 oxine [31].

Gene context of Gamma Cameras

  • [111In-DTPA]octreotide was developed for gamma camera imaging of SRIF receptor-positive malignancies, such as gasteroenteropancreatic tumors [32].
  • Planar gamma-camera images over known tumor sites were acquired 1 h after the injection of 111-185 MBq of 99mTc-IL2 [33].
  • Somatostatin analogues, labeled with gamma-emitting radionuclides, are of potential value in the localization of somatostatin receptor-positive tumors with gamma camera imaging [34].
  • Somatostatin receptor specificity of tumor uptake was confirmed by pretreatment, competition, and displacement experiments in vivo using 0.8 mg TOC/kg and gamma-camera imaging [35].
  • PET has greater sensitivity than gamma-camera imaging and therefore would have an advantage for the imaging of SSTR2 gene transfer [36].

Analytical, diagnostic and therapeutic context of Gamma Cameras


  1. Radioimmunodetection of prostatic cancer. In vivo use of radioactive antibodies against prostatic acid phosphatase for diagnosis and detection of prostatic cancer by nuclear imaging. Goldenberg, D.M., DeLand, F.H., Bennett, S.J., Primus, F.J., Nelson, M.O., Flanigan, R.C., McRoberts, J.W., Bruce, A.W., Mahan, D.E. JAMA (1983) [Pubmed]
  2. Carcinoembryonic antigen radioimmunodetection in the evaluation of colorectal cancer and in the detection of occult neoplasms. Goldenberg, D.M., Kim, E.E., Bennett, S.J., Nelson, M.O., Deland, F.H. Gastroenterology (1983) [Pubmed]
  3. Human cholangiocarcinomas express somatostatin receptors and respond to somatostatin with growth inhibition. Tan, C.K., Podila, P.V., Taylor, J.E., Nagorney, D.M., Wiseman, G.A., Gores, G.J., LaRusso, N.F. Gastroenterology (1995) [Pubmed]
  4. Noninvasive quantitation of myocardial infarction with technetium 99m pyrophosphate. Botvinick, E.H., Shames, D., Lappin, H., Tyberg, J.V., Townsend, R., Parmley, W.W. Circulation (1975) [Pubmed]
  5. Reduced left ventricular myocardial blood flow per unit mass in aortic stenosis. Johnson, L.L., Sciacca, R.R., Ellis, K., Weiss, M.B., Cannon, P.J. Circulation (1978) [Pubmed]
  6. Dynamic scanning defines a colonic defect in severe idiopathic constipation. Kamm, M.A., Lennard-Jones, J.E., Thompson, D.G., Sobnack, R., Garvie, N.W., Granowska, M. Gut (1988) [Pubmed]
  7. Tumor imaging with radioactive metal chelates conjugated to monoclonal antibodies. Scheinberg, D.A., Strand, M., Gansow, O.A. Science (1982) [Pubmed]
  8. Albumin lung/heart ratio change. A simple clinical means of documenting increased pulmonary endothelial permeability to protein. Mishkin, F.S., Niden, A., Kumar, A., Thomas, A., Reese, I.C., Vasinrapee, P. JAMA (1987) [Pubmed]
  9. Specific localization and imaging of amyloid deposits in vivo using 123I-labeled serum amyloid P component. Hawkins, P.N., Myers, M.J., Epenetos, A.A., Caspi, D., Pepys, M.B. J. Exp. Med. (1988) [Pubmed]
  10. Beta receptor occupancy. Assessment in the intact animal. Homcy, C.J., Strauss, H.W., Kopiwoda, S. J. Clin. Invest. (1980) [Pubmed]
  11. Localisation of endocrine-related tumours with radioiodinated analogue of somatostatin. Krenning, E.P., Bakker, W.H., Breeman, W.A., Koper, J.W., Kooij, P.P., Ausema, L., Lameris, J.S., Reubi, J.C., Lamberts, S.W. Lancet (1989) [Pubmed]
  12. Deep arterial injury during experimental angioplasty: relation to a positive indium-111-labeled platelet scintigram, quantitative platelet deposition and mural thrombosis. Lam, J.Y., Chesebro, J.H., Steele, P.M., Dewanjee, M.K., Badimon, L., Fuster, V. J. Am. Coll. Cardiol. (1986) [Pubmed]
  13. Clinical evaluation of patients with hypertension and exercise-induced renal dysfunction. Clorius, J.H., Mann, J., Schmidlin, P., Strauss, L.G., Saur, T., Irngartinger, G. Hypertension (1987) [Pubmed]
  14. Renovascular hypertension identified by captopril-induced changes in the renogram. Geyskes, G.G., Oei, H.Y., Puylaert, C.B., Mees, E.J. Hypertension (1987) [Pubmed]
  15. The use of technetium-99m sulfur colloid as a marker for experimental venous thrombosis: concise communication. Bardfeld, P.A., Rand, J., Goldsmith, S.J. J. Nucl. Med. (1981) [Pubmed]
  16. Feasibility of planar fluorine-18-FDG imaging after recent myocardial infarction to assess myocardial viability. Huitink, J.M., Visser, F.C., van Lingen, A., Groeneveld, A.B., Bax, J.J., van Leeuwen, G.R., Visser, G.M., Van Loon, M.J., Teule, G.J., Visser, C.A. J. Nucl. Med. (1995) [Pubmed]
  17. Effect of metoclopramide in chronic gastric retention after gastric surgery. Metzger, W.H., Cano, R., Sturdevant, R.A. Gastroenterology (1976) [Pubmed]
  18. Simultaneous assessment of myocardial perfusion and left ventricular function during transient coronary occlusion. Gallik, D.M., Obermueller, S.D., Swarna, U.S., Guidry, G.W., Mahmarian, J.J., Verani, M.S. J. Am. Coll. Cardiol. (1995) [Pubmed]
  19. Effects of acute, transient coronary occlusion on global and regional right ventricular function in humans. Verani, M.S., Guidry, G.W., Mahmarian, J.J., Nishimura, S., Athanasoulis, T., Roberts, R., Lacy, J.L. J. Am. Coll. Cardiol. (1992) [Pubmed]
  20. The effect of aerosol distribution on airway responsiveness to inhaled methacholine in patients with asthma. Laube, B.L., Norman, P.S., Adams, G.K. J. Allergy Clin. Immunol. (1992) [Pubmed]
  21. Dual therapy of ovarian cancer using measles viruses expressing carcinoembryonic antigen and sodium iodide symporter. Hasegawa, K., Pham, L., O'Connor, M.K., Federspiel, M.J., Russell, S.J., Peng, K.W. Clin. Cancer Res. (2006) [Pubmed]
  22. Myocardial kinetics of Tc-MIBI in canine myocardium after dipyridamole. Glover, D.K., Okada, R.D. Circulation (1990) [Pubmed]
  23. Noninvasive radioisotopic technique for detection of platelet deposition in coronary artery bypass grafts in dogs and its reduction with platelet inhibitors. Fuster, V., Dewanjee, M.K., Kaye, M.P., Josa, M., Metke, M.P., Chesebro, J.H. Circulation (1979) [Pubmed]
  24. A phase I trial of monoclonal antibody M195 in acute myelogenous leukemia: specific bone marrow targeting and internalization of radionuclide. Scheinberg, D.A., Lovett, D., Divgi, C.R., Graham, M.C., Berman, E., Pentlow, K., Feirt, N., Finn, R.D., Clarkson, B.D., Gee, T.S. J. Clin. Oncol. (1991) [Pubmed]
  25. Lithium as a potential adjuvant to 131I therapy of metastatic, well differentiated thyroid carcinoma. Koong, S.S., Reynolds, J.C., Movius, E.G., Keenan, A.M., Ain, K.B., Lakshmanan, M.C., Robbins, J. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  26. Measurement of lung tissue mass in Pneumocystis carinii pneumonia. Seddon, D.J., Snashall, P.D. Thorax (1989) [Pubmed]
  27. Regional lung clearance of excessive bronchial secretions during chest physiotherapy in patients with stable chronic airways obstruction. Bateman, J.R., Newman, S.P., Daunt, K.M., Pavia, D., Clarke, S.W. Lancet (1979) [Pubmed]
  28. Scintigraphic determination of small intestinal transit time: comparison with the hydrogen breath technique. Caride, V.J., Prokop, E.K., Troncale, F.J., Buddoura, W., Winchenbach, K., McCallum, R.W. Gastroenterology (1984) [Pubmed]
  29. Distinguishing benign from malignant euadrenal masses. Gross, M.D., Shapiro, B., Bouffard, J.A., Glazer, G.M., Francis, I.R., Wilton, G.P., Khafagi, F., Sonda, L.P. Ann. Intern. Med. (1988) [Pubmed]
  30. The use of preintervention and postintervention thallium imaging for assessing the early and late effects of experimental coronary arterial reperfusion in dogs. Okada, R.D., Pohost, G.M. Circulation (1984) [Pubmed]
  31. Heparin-resistant thrombus formation by endovascular stents in baboons. Interruption by a synthetic antithrombin. Krpski, W.C., Bass, A., Kelly, A.B., Marzec, U.M., Hanson, S.R., Harker, L.A. Circulation (1990) [Pubmed]
  32. Somatostatin analogs for diagnosis and treatment of cancer. Weckbecker, G., Raulf, F., Stolz, B., Bruns, C. Pharmacol. Ther. (1993) [Pubmed]
  33. 99mTc-interleukin-2 scintigraphy as a potential tool for evaluating tumor-infiltrating lymphocytes in melanoma lesions: a validation study. Signore, A., Annovazzi, A., Barone, R., Bonanno, E., D'Alessandria, C., Chianelli, M., Mather, S.J., Bottoni, U., Panetta, C., Innocenzi, D., Scopinaro, F., Calvieri, S. J. Nucl. Med. (2004) [Pubmed]
  34. In vivo use of a radioiodinated somatostatin analogue: dynamics, metabolism, and binding to somatostatin receptor-positive tumors in man. Bakker, W.H., Krenning, E.P., Breeman, W.A., Kooij, P.P., Reubi, J.C., Koper, J.W., de Jong, M., Laméris, J.S., Visser, T.J., Lamberts, S.W. J. Nucl. Med. (1991) [Pubmed]
  35. Improvement of pharmacokinetics of radioiodinated Tyr(3)-octreotide by conjugation with carbohydrates. Schottelius, M., Wester, H.J., Reubi, J.C., Senekowitsch-Schmidtke, R., Schwaiger, M. Bioconjug. Chem. (2002) [Pubmed]
  36. MicroPET imaging of gene transfer with a somatostatin receptor-based reporter gene and (94m)Tc-Demotate 1. Rogers, B.E., Parry, J.J., Andrews, R., Cordopatis, P., Nock, B.A., Maina, T. J. Nucl. Med. (2005) [Pubmed]
  37. Noninvasive evaluation of regional myocardial perfusion in 112 patients using a mobile scintillation camera and intravenous nitrogen-13 labeled ammonia. Walsh, W.F., Harper, P.V., Resnekov, L., Fill, H. Circulation (1976) [Pubmed]
  38. In vitro autoradiographic and in vivo scintigraphic localization of somatostatin receptors in human lymphatic tissue. Reubi, J.C., Waser, B., Horisberger, U., Krenning, E., Lamberts, S.W., Gebbers, J.O., Gersbach, P., Laissue, J.A. Blood (1993) [Pubmed]
  39. Non-invasive gamma camera imaging of gene transfer using an adenoviral vector encoding an epitope-tagged receptor as a reporter. Rogers, B.E., Chaudhuri, T.R., Reynolds, P.N., Della Manna, D., Zinn, K.R. Gene Ther. (2003) [Pubmed]
  40. Mesenteric vascular occlusion: a new diagnostic method using a radiolabeled monoclonal antibody reactive with platelets. Oster, Z.H., Som, P., Zamora, P.O. Radiology. (1989) [Pubmed]
  41. Quantitative evaluation of iodine-123 hippuran gamma camera renography in normal children. Carlsen, O., Kvinesdal, B., Nathan, E. J. Nucl. Med. (1986) [Pubmed]
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