The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Respiratory acidemia and theophylline pharmacokinetics in the awake dog.

Recently, respiratory acidemia has been shown to be associated with an altered volume of distribution (Vd) of theophylline in patients during an acute exacerbation of chronic obstructive pulmonary disease. However, many factors other than acidemia could have altered the pharmacokinetics. Our purpose was to study the effects of respiratory acidemia alone. Six awake dogs had normocapnia and hypercapnia induced in a conditioned chamber. After intravenous injection (8 mg/kg), plasma theophylline concentrations were measured for 8 hours by means of quantitative enzyme immunoassay technique. There were no statistically significant effects of respiratory acidosis on Vd and total theophylline clearance. There was no significant correlation between these variables and pH, PCO2, PO2. We conclude that respiratory acidosis, per se, does not effect theophylline pharmacokinetics in dogs.[1]


  1. Respiratory acidemia and theophylline pharmacokinetics in the awake dog. Clozel, J.P., Saunier, C., Royer-Morot, M.J., Royer, R.J., Sadoul, P. Chest (1981) [Pubmed]
WikiGenes - Universities