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Niwaguchi, T. et al.

Excretion of methoxyphenamine and its metabolites in rat urine.

Metabolites of methoxyphenamine in urine obtained after oral administration of the drug to rats have been isolated by Sephadex LH-20 column chromatography and identified as the O-, N,O- and N-demethylated derivatives of methoxyphenamine by thin-layer chromatography, spectrometry, and comparisons with synthesized compounds. The unchanged drug and the metabolites excreted in urine have been extracted and determined by gas chromatography after treatment with trifluoroacetic anhydride.[1]

References

Excretion of methoxyphenamine and its metabolites in rat urine. Niwaguchi, T., Inoue, T. J. Chromatogr. (1978) [Pubmed]

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