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Chemical Compound Review

TFAA     2,2,2-trifluoroethanoyl 2,2,2...

Synonyms: PubChem12672, ACMC-1AQ23, ANW-29482, NSC-96965, AC1L1TYD, ...
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Disease relevance of Perfluoroacetic anhydride


High impact information on Perfluoroacetic anhydride


Biological context of Perfluoroacetic anhydride


Associations of Perfluoroacetic anhydride with other chemical compounds


Gene context of Perfluoroacetic anhydride

  • Derivatization with trifluoroacetic anhydride of nor1 and nor2 metabolites allowed the chromatographic separation of these compounds [15].
  • A method is described for the GC-NPD determination of urinary codeine and morphine after derivatization with trifluoroacetic anhydride [16].
  • After derivatization with trifluoroacetic anhydride, the drugs were separated on a 25-m capillary column BP 10 and detected by selected ion monitoring [17].
  • Treatment of gramicidin S (GS) with trifluoroacetic anhydride afforded a derivative in which only one of the two Orn side chains was trifluoroacetylated in 72% yield, furnishing the first efficient method for the preparation of a monoprotected derivative of GS [18].
  • Methyl- and ethylphenidate are then derivatized by the addition of 50 ML of trifluoroacetic anhydride and the TFA derivatives are injected into a quadrupole GC/MS for analysis [19].

Analytical, diagnostic and therapeutic context of Perfluoroacetic anhydride


  1. GLC determination of nicotinamide in multivitamin formulations after conversion to nicotinonitrile. Vessman, J., Strömberg, S. Journal of pharmaceutical sciences. (1975) [Pubmed]
  2. Chemical burn due to trifluoroacetic anhydride. Nakamura, M., Miyachi, Y. Contact Derm. (2002) [Pubmed]
  3. Characterization of acetylated and acetolyzed glycoprotein high-mannose core oligosaccharides by fast-atom-bombardment mass spectrometry. Tsai, P.K., Dell, A., Ballou, C.E. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  4. Trifluoroacetic anhydride-mediated solid-phase version of the Robinson-Gabriel synthesis of oxazoles. Pulici, M., Quartieri, F., Felder, E.R. Journal of combinatorial chemistry. (2005) [Pubmed]
  5. Hemoglobin and albumin adducts of benzene oxide among workers exposed to high levels of benzene. Yeowell-O'Connell, K., Rothman, N., Smith, M.T., Hayes, R.B., Li, G., Waidyanatha, S., Dosemeci, M., Zhang, L., Yin, S., Titenko-Holland, N., Rappaport, S.M. Carcinogenesis (1998) [Pubmed]
  6. Facile acylation of glycerophosphocholine catalyzed by trifluoroacetic anhydride. Kanda, P., Wells, M.A. J. Lipid Res. (1981) [Pubmed]
  7. Aromatic hydroxylation of beta-adrenergic antagonists. Formation of 4'- and 5'-hydroxy-1-(isopropylamino)-3-[2'-allyloxy)phenoxy]-2-propanol from oxprenolol. Nelson, W.L., Burke, T.R. J. Med. Chem. (1979) [Pubmed]
  8. Inhibitors of polyamine biosynthesis VI: 2,5-Diamino-2-(cyanomethyl) pentanoic acid, a potential irreversible inhibitor of ornithine decarboxylase. Abdel-Monem, M.M., Mikhail, E.A. Journal of pharmaceutical sciences. (1978) [Pubmed]
  9. Derivatization of aminoalkylphosphonic acids for characterization by gas chromatography mass spectrometry. Rueppel, M.L., Suba, L.A., Marvel, J.T. Biomed. Mass Spectrom. (1976) [Pubmed]
  10. The first examples of Nazarov cyclizations leading to annulated pyrroles. Song, C., Knight, D.W., Whatton, M.A. Org. Lett. (2006) [Pubmed]
  11. Simultaneous determination of [2-15N]- and [5-15N]glutamine with gas chromatography-mass spectroscopy: applications to nitrogen metabolic studies. Nissim, I., Yudkoff, M., Lapidot, A. Anal. Biochem. (1984) [Pubmed]
  12. Trifluoroacetic anhydride-catalyzed nitration of toluene as an approach to the specific analysis of nitrate by gas chromatography-mass spectrometry. Smythe, G.A., Matanovic, G., Yi, D., Duncan, M.W. Nitric Oxide (1999) [Pubmed]
  13. Multiresidue method for the determination of avermectin and moxidectin residues in the liver using HPLC with fluorescence detection. Roudaut, B. The Analyst. (1998) [Pubmed]
  14. Improved method for determination of abamectin and ivermectin in cattle plasma. Wei, G.Z., Li, J.S. Journal of AOAC International. (2001) [Pubmed]
  15. Isothermal gas chromatographic determination of nanogram amounts of chlorimipramine, chlorpromazine and their N-desmethyl metabolites in plasma using nitrogen-selective detection. Ninci, R., Giovannini, M.G., Della Corte, L., Sgaragli, G. J. Chromatogr. (1986) [Pubmed]
  16. Influence of hydrolysis procedures on the urinary concentrations of codeine and morphine in relation to doping analysis. Delbeke, F.T., Debackere, M. Journal of pharmaceutical and biomedical analysis. (1993) [Pubmed]
  17. Identification by GC/MS of 6-monoacetylmorphine as an indicator of heroin abuse. Kintz, P., Mangin, P., Lugnier, A.A., Chaumont, A.J. Eur. J. Clin. Pharmacol. (1989) [Pubmed]
  18. Convenient preparation of [Orn(Tfa)2]- and [Orn(Boc)2, Orn(Tfa)2]gramicidin S, versatile unsymmetrically protected derivatives of gramicidin S. Yamada, K., Ando, K., Takahashi, Y., Yamamura, H., Araki, S., Kawai, M. J. Pept. Res. (1999) [Pubmed]
  19. Gas chromatographic/mass spectrometric analysis of methylphenidate (ritalin) in serum. Chan, Y.M., Soldin, S.J., Swanson, J.M., Deber, C.M., Thiessen, J.J., Macleod, S. Clin. Biochem. (1980) [Pubmed]
  20. Multivariate analyses of carbohydrate data from lipopolysaccharides of Actinobacillus (Haemophilus) actinomycetemcomitans, Haemophilus aphrophilus, and Haemophilus paraphrophilus. Brondz, I., Olsen, I. Int. J. Syst. Bacteriol. (1990) [Pubmed]
  21. Excretion of methoxyphenamine and its metabolites in rat urine. Niwaguchi, T., Inoue, T. J. Chromatogr. (1978) [Pubmed]
  22. Solid-phase extraction-gas chromatography and solid-phase extraction-gas chromatography-mass spectrometry determination of corrosion inhibiting long-chain primary alkyl amines in chemical treatment of boiler water in water-steam systems of power plants. Kusch, P., Knupp, G., Hergarten, M., Kozupa, M., Majchrzak, M. Journal of chromatography. A. (2006) [Pubmed]
  23. Multiresidue determination of abamectin, doramectin, ivermectin, and moxidectin in milk using liquid chromatography and fluorescence detection. Schenck, F.J., Lagman, L.H. Journal of AOAC International. (1999) [Pubmed]
  24. An automated method for the determination of subnanogram concentrations of eprinomectin in bovine plasma. Antonian, L., DeMontigny, P., Wislocki, P.G. Journal of pharmaceutical and biomedical analysis. (1998) [Pubmed]
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