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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Thiol oxidation in the crystalline lens. I. The rate-limiting role of hexokinase in aging rat and human lenses.

Reduction of nonprotein disulfides required both glucose or glucose-6-phosphate (G6P) and nicotinamide adenine dinucleotide phosphate (NADP). However, hexokinase ( HK) was found to be the rate-limiting step: the glucose-supported reduction rate was only 50% of that of G6P-supported activity. This disulfide-reducing activity seemed to decline in the aging lens. Further, the glucose-supported activity dropped substantially if HK was deactivated with diamide; the deactivation was partially reversible. HK activity in aging clear and cataractous human lenses had greatly diminished. This might explain the disproportionate decrease in glucose-supported reduction in the aging lens. The components of the disulfide-reducing mechanism in human lens were reviewed and discussed.[1]

References

  1. Thiol oxidation in the crystalline lens. I. The rate-limiting role of hexokinase in aging rat and human lenses. Cheng, H.M., Chylack, L.T. Invest. Ophthalmol. Vis. Sci. (1980) [Pubmed]
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