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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Lens, Crystalline

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Disease relevance of Lens, Crystalline


Psychiatry related information on Lens, Crystalline


High impact information on Lens, Crystalline

  • These allelic cataract mutations provide the first direct evidence that MIP plays a crucial role in the development of a transparent eye lens [7].
  • The murine Elo (eye lens obsolescence) mutation confers a dominant phenotype characterized by malformation of the eye lens [8].
  • The eye lens contains a structural protein (alpha-crystallin), composed of two homologous primary gene products, alpha A2 and alpha B2 [9].
  • We now show that protein S has a striking homology with the beta- and gamma-crystallins of the vertebrate eye lens which are beta-sheet proteins with internally duplicated structures [10].
  • The three-dimensional structure of the eye lens protein, bovine gamma-crystallin II, has been determined at 2.6 A resolution [11].

Chemical compound and disease context of Lens, Crystalline


Biological context of Lens, Crystalline


Anatomical context of Lens, Crystalline


Associations of Lens, Crystalline with chemical compounds


Gene context of Lens, Crystalline

  • For AR two primers (derived from the sequence of the rat eye lens) were chosen which amplify a 668-bp product [27].
  • Of importance, the level of cyclin D1 was also elevated in eye lens of the c-mos-transgenic mice compared to normal mice [28].
  • Gamma-crystallin genes are specifically expressed in the eye lens [29].
  • The sequence relationship between the small heat shock proteins and the eye lens protein alpha-crystallin (Ingolia, T. D., and E. E. Craig, 1982, Proc. Natl. Acad. Sci. USA, 79: 2360-2364) prompted us to subject rat lenses in organ culture to heat shock and other forms of stress [30].
  • alpha A-crystallin (alpha A) and alpha B-crystallin (alpha B) are among the predominant proteins of the vertebrate eye lens [31].

Analytical, diagnostic and therapeutic context of Lens, Crystalline


  1. Expression of the murine small heat shock proteins hsp 25 and alpha B crystallin in the absence of stress. Klemenz, R., Andres, A.C., Fröhli, E., Schäfer, R., Aoyama, A. J. Cell Biol. (1993) [Pubmed]
  2. Do blue light filters confer protection against age-related macular degeneration? Margrain, T.H., Boulton, M., Marshall, J., Sliney, D.H. Progress in retinal and eye research. (2004) [Pubmed]
  3. Calorimetric analysis of the Ca(2+)-binding betagamma-crystallin homolog protein S from Myxococcus xanthus: intrinsic stability and mutual stabilization of domains. Wenk, M., Jaenicke, R. J. Mol. Biol. (1999) [Pubmed]
  4. Heterologous expression in Escherichia coli of native and mutant forms of the major intrinsic protein of rat eye lens (MIP26). Dilsiz, N., Crabbe, M.J. Biochem. J. (1995) [Pubmed]
  5. Pathogenesis of transient high myopia after blunt eye trauma. Ikeda, N., Ikeda, T., Nagata, M., Mimura, O. Ophthalmology (2002) [Pubmed]
  6. A novel method for the amino acid sequence/configuration determination of peptides containing D/L-amino acids utilizing a fluorogenic Edman reagent, 7-N,N-dimethylaminosulphonyl-4-(2,1,3-benzoxadiazolyl)isothiocyanate (DBD-NCS). Imai, K., Matsunaga, H., Fukushima, T., Santa, T., Homma, H., Nakashima, K., Akiyama, S. Biomed. Chromatogr. (1995) [Pubmed]
  7. Mutations in the founder of the MIP gene family underlie cataract development in the mouse. Shiels, A., Bassnett, S. Nat. Genet. (1996) [Pubmed]
  8. A frameshift mutation in the gamma E-crystallin gene of the Elo mouse. Cartier, M., Breitman, M.L., Tsui, L.C. Nat. Genet. (1992) [Pubmed]
  9. Alternative RNA splicing of the murine alpha A-crystallin gene: protein-coding information within an intron. King, C.R., Piatigorsky, J. Cell (1983) [Pubmed]
  10. Myxococcus xanthus spore coat protein S may have a similar structure to vertebrate lens beta gamma-crystallins. Wistow, G., Summers, L., Blundell, T. Nature (1985) [Pubmed]
  11. The molecular structure and stability of the eye lens: x-ray analysis of gamma-crystallin II. Blundell, T., Lindley, P., Miller, L., Moss, D., Slingsby, C., Tickle, I., Turnell, B., Wistow, G. Nature (1981) [Pubmed]
  12. Characterization of the Rickettsia prowazekii pepA gene encoding leucine aminopeptidase. Wood, D.O., Solomon, M.J., Speed, R.R. J. Bacteriol. (1993) [Pubmed]
  13. Ocular effects of second generation oral hypoglycemic agents. Lightman, J.M., Townsend, J.C., Selvin, G.J. Journal of the American Optometric Association. (1989) [Pubmed]
  14. Human multidrug resistance 3-P-glycoprotein expression in transgenic mice induces lens membrane alterations leading to cataract. Dunia, I., Smit, J.J., van der Valk, M.A., Bloemendal, H., Borst, P., Benedetti, E.L. J. Cell Biol. (1996) [Pubmed]
  15. The primary structure of leucine aminopeptidase from bovine eye lens. Cuypers, H.T., van Loon-Klaassen, L.A., Egberts, W.T., de Jong, W.W., Bloemendal, H. J. Biol. Chem. (1982) [Pubmed]
  16. Age-associated oxidative damage leads to absence of gamma-cystathionase in over 50% of rat lenses: relevance in cataractogenesis. Sastre, J., Martín, J.A., Gómez-Cabrera, M.C., Pereda, J., Borrás, C., Pallardó, F.V., Viña, J. Free Radic. Biol. Med. (2005) [Pubmed]
  17. Ethylnitrosourea-induced mutation in mice leads to the expression of a novel protein in the eye and to dominant cataracts. Graw, J., Klopp, N., Löster, J., Soewarto, D., Fuchs, H., Becker-Follmann, J., Reis, A., Wolf, E., Balling, R., Habré de Angelis, M. Genetics (2001) [Pubmed]
  18. Comparison of the proteins of two immunologically distinct intermediate-sized filaments by amino acid sequence analysis: desmin and vimentin. Geisler, N., Weber, K. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  19. Peripheral neuropathy in mice transgenic for a human MDR3 P-glycoprotein mini-gene. Smit, J.J., Baas, F., Hoogendijk, J.E., Jansen, G.H., van der Valk, M.A., Schinkel, A.H., Berns, A.J., Acton, D., Nooter, K., Burger, H., Smith, S.J., Borst, P. J. Neurosci. (1996) [Pubmed]
  20. Vimentin and CP49/filensin form distinct networks in the lens which are independently modulated during lens fibre cell differentiation. Sandilands, A., Prescott, A.R., Carter, J.M., Hutcheson, A.M., Quinlan, R.A., Richards, J., FitzGerald, P.G. J. Cell. Sci. (1995) [Pubmed]
  21. Effects of naphthalene metabolites on cultured cells from eye lens. Russell, P., Yamada, T., Xu, G.T., Garland, D., Zigler, J.S. Free Radic. Biol. Med. (1991) [Pubmed]
  22. Co-axial association of recombinant eye lens aquaporin-0 observed in loosely packed 3D crystals. Palanivelu, D.V., Kozono, D.E., Engel, A., Suda, K., Lustig, A., Agre, P., Schirmer, T. J. Mol. Biol. (2006) [Pubmed]
  23. Interspecies variations in mammalian lens metabolites as detected by phosphorus-31 nuclear magnetic resonance. Kopp, S.J., Glonek, T., Greiner, J.V. Science (1982) [Pubmed]
  24. The role of ascorbic acid in senile cataract. Bensch, K.G., Fleming, J.E., Lohmann, W. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  25. Effect of polyethylene glycol on the liquid-liquid phase transition in aqueous protein solutions. Annunziata, O., Asherie, N., Lomakin, A., Pande, J., Ogun, O., Benedek, G.B. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  26. Enzyme/crystallins and extremely high pyridine nucleotide levels in the eye lens. Zigler, J.S., Rao, P.V. FASEB J. (1991) [Pubmed]
  27. Rat renal expression of mRNA coding for aldose reductase and sorbitol dehydrogenase and its osmotic regulation in inner medullary collecting duct cells. Grunewald, R.W., Wagner, M., Schubert, I., Franz, H.E., Müller, G.A., Steffgen, J. Cell. Physiol. Biochem. (1998) [Pubmed]
  28. Elevated level of cyclin D1 in mos-transformed cells. Yang, Y., Pham, C.D., Arlinghaus, R.B., Khillan, J.S., Singh, B. Int. J. Oncol. (1998) [Pubmed]
  29. Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter. Lengler, J., Krausz, E., Tomarev, S., Prescott, A., Quinlan, R.A., Graw, J. Nucleic Acids Res. (2001) [Pubmed]
  30. Heat shock response of the rat lens. de Jong, W.W., Hoekman, W.A., Mulders, J.W., Bloemendal, H. J. Cell Biol. (1986) [Pubmed]
  31. Targeted disruption of the mouse alpha A-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat shock protein alpha B-crystallin. Brady, J.P., Garland, D., Duglas-Tabor, Y., Robison, W.G., Groome, A., Wawrousek, E.F. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  32. ACTH-like peptides in postimplantation mouse embryos: a possible role in myoblast proliferation and muscle histogenesis. De Angelis, L., Cusella-De Angelis, M.G., Bouchè, M., Vivarelli, E., Boitani, C., Molinaro, M., Cossu, G. Dev. Biol. (1992) [Pubmed]
  33. Spectral sensitivity of the pseudophakic eye. Werner, J.S., Hardenbergh, F.E. Arch. Ophthalmol. (1983) [Pubmed]
  34. Organ culture and immunohistochemistry of the genetically malformed lens, in eye lens obsolescence, Elo, of the mouse. Watanabe, K., Fujisawa, H., Oda, S., Kameyama, Y. Exp. Eye Res. (1980) [Pubmed]
  35. Electrophoretic titration curve in 6 M urea of the bovine eye lens protein alpha-crystallin. van den Oetelaar, P.J., Hoenders, H.J. J. Chromatogr. (1987) [Pubmed]
  36. Analysis of cytoskeletal proteins in posterior capsule opacification after implantation of acrylic and hydrogel intraocular lenses. Matsushima, H., Mukai, K., Obara, Y., Yoshida, S., Clark, J.I. Journal of cataract and refractive surgery. (2004) [Pubmed]
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