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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Effect of dose fractionation of daunorubicin on survival of leukemic cells.

Mice bearing transplanted AKR leukemia received daunorubicin either as a single dose or as four equally divided doses (0.2 mg/mouse; four times) with the time interval between the divided doses varying from 12 to 36 hr; survival of leukemia colony-forming cells was then assayed. When daunorubicin was administered in any of the fractionated schedules, the dose-survival curve was exponential with a shoulder region demonstrable. As expected, there was significantly less cell killing for the fractionated schedule than for a comparable accumulated single dose; however, with administration of the fourth dose for any interval studied, the increment in cell killing was so large that it was quite similar to that resulting from a single 0.8-mg/mouse dose. We examined the time course of cell killing for the 24-hr fractionation schedule and found greater killing than expected after each subsequent dose with the most pronounced increase occurring after the fourth dose. Possible mechanisms for this effect are discussed.[1]


  1. Effect of dose fractionation of daunorubicin on survival of leukemic cells. Razek, A., Valeriote, F., Vietti, T. Cancer Res. (1980) [Pubmed]
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