Disease relevance of Dose Fractionation

• We conducted a dose fractionation study of neutropenic, corticosteroid-immunosuppressed mice to characterize the pharmacodynamic/pharmacokinetic (PK/PD) parameter most closely associated with amphotericin B (AMB) efficacy in the treatment of invasive pulmonary aspergillosis [1].
• Synergism between hyperthermia and cyclophosphamide in vivo: the effect of dose fractionation [2].
• Using clinically relevant dose-fractionation schedules in a mouse tumour model, the addition of carbogen and nicotinamide to overcome chronic and acute hypoxia results in a marked increase in radioresponsiveness with a lower degree of sensitization in normal tissue [3].
• Nonetheless, the dose fractionation regimen of 25 Gy in 10 fractions with combination chemotherapy, cyclophosphamide, doxorubicin (or methotrexate), and vincristine is as effective in eliminating subclinical metastasis to the brain [4].
• HDR monotherapy with large-dose fraction sizes might achieve superior tumor control compared with LDR, especially if prostate cancer possesses a high sensitivity to dose fractionation (i.e., if the alpha/beta ratio is low) [5].

High impact information on Dose Fractionation

• Because of its high mutagenicity, ethylnitrosourea can serve as a model compound in exploring the effect of such factors as dose response, dose fractionation, sex, and cell stage on the mutagenic action of a chemical [6].
• Effect of cycloheximide or puromycin on induction of thermotolerance by heat in Chinese hamster ovary cells: dose fractionation at 45.5 degrees C1 [7].
• Effect of dose fractionation of daunorubicin on survival of leukemic cells [8].
• Dose fractionation was used to simulate concentrations of gemifloxacin in human serum associated with 640 mg every 48 h (one dose), 320 mg every 24 h (two doses), and 160 mg every 12 h (four doses) [9].
• Thus, dose-fractionation studies demonstrated that the pharmacodynamic parameter of fluconazole that best predicted outcome was the AUC/MIC ratio [10].

Anatomical context of Dose Fractionation

• The relative importance of the effects of dose rate, dose fractionation, and prior exposure to Cytoxan on the recovery of cells in the bone marrow, following conditioning for BMT, remains controversial [11].
• Multiple gamma ray dose fractionation effects were studied using contact-inhibited C3H 10T 1/2 murine fibroblast cultures in an attempt to simulate conditions in tissues with low rates of cell turnover [12].
• The effect of dose fractionation on the frequency of ethylnitrosourea-induced dominant cataract and recessive specific locus mutations in germ cells of the mouse [13].

Associations of Dose Fractionation with chemical compounds

• In vivo radiosensitizing activity of a new fluorinated hypoxic cell radiosensitizer, KU-2285, in combination with radiation dose fractionation [14].
• The low rate of cardiotoxicity appeared to be related to dose fractionation of epirubicin [15].
• The interactive effect is maintained in a clinically relevant dose fractionation schedule whereby 8 fractions of 2 Gy each were pretreated 6 hr before with 80 mg/kg tubulozole [16].
• Examination of the split-dose survival curves for BrdUrd and UVB light in the presence or absence of caffeine indicates that sensitization by caffeine is completely independent of the sparing effect of dose fractionation [17].
• Comparing and combining light dose fractionation and iron chelation to enhance experimental photodynamic therapy with aminolevulinic acid [18].

Gene context of Dose Fractionation

• In this report, we show that cells irradiated in the same S phase after BrdUrd incorporation demonstrate an ability to repair sublethal damage, in contrast to the lack of an increase in survival with dose fractionation in template-labeled cells (Ben-Hur, E., and M. M. Elkind. Mutat. Res. 1972. 14:236-245) [19].
• Dose-rate effects in mammalian cells: V. Dose fractionation effects in noncycling C3H 10T 1/2 cells [12].
• Evaluation of the ECAT EXACT HR+ 3-D PET scanner in H2(15)O brain activation studies: dose fractionation strategies for rCBF and signal enhancing protocols [20].
• Present analysis shows that the empirical models as the NSD and TDF do not predict correctly, the late normal tissue damage for different dose fractionations [21].
• STUDY DESIGN/MATERIALS AND METHODS: In normal rat colon, CP94 administration and light dose fractionation were independently and concurrently employed to enhance ALA-PDT [18].

Analytical, diagnostic and therapeutic context of Dose Fractionation

• Therefore, no decrease in normal tissue tolerance should be observed with the use of nicotinamide in clinical radiotherapy resulting either from reduced sparing with dose fractionation or from an increase in residual damage when shortening the interfraction interval [22].

References