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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Dose Fractionation

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Disease relevance of Dose Fractionation


High impact information on Dose Fractionation


Anatomical context of Dose Fractionation


Associations of Dose Fractionation with chemical compounds


Gene context of Dose Fractionation

  • In this report, we show that cells irradiated in the same S phase after BrdUrd incorporation demonstrate an ability to repair sublethal damage, in contrast to the lack of an increase in survival with dose fractionation in template-labeled cells (Ben-Hur, E., and M. M. Elkind. Mutat. Res. 1972. 14:236-245) [19].
  • Dose-rate effects in mammalian cells: V. Dose fractionation effects in noncycling C3H 10T 1/2 cells [12].
  • Evaluation of the ECAT EXACT HR+ 3-D PET scanner in H2(15)O brain activation studies: dose fractionation strategies for rCBF and signal enhancing protocols [20].
  • Present analysis shows that the empirical models as the NSD and TDF do not predict correctly, the late normal tissue damage for different dose fractionations [21].
  • STUDY DESIGN/MATERIALS AND METHODS: In normal rat colon, CP94 administration and light dose fractionation were independently and concurrently employed to enhance ALA-PDT [18].

Analytical, diagnostic and therapeutic context of Dose Fractionation

  • Therefore, no decrease in normal tissue tolerance should be observed with the use of nicotinamide in clinical radiotherapy resulting either from reduced sparing with dose fractionation or from an increase in residual damage when shortening the interfraction interval [22].


  1. Pharmacodynamic activity of amphotericin B deoxycholate is associated with peak plasma concentrations in a neutropenic murine model of invasive pulmonary aspergillosis. Wiederhold, N.P., Tam, V.H., Chi, J., Prince, R.A., Kontoyiannis, D.P., Lewis, R.E. Antimicrob. Agents Chemother. (2006) [Pubmed]
  2. Synergism between hyperthermia and cyclophosphamide in vivo: the effect of dose fractionation. Hazan, G., Ben-Hur, E., Yerushalmi, A. European journal of cancer. (1981) [Pubmed]
  3. Short communication: the addition of carbogen and nicotinamide to a palliative fractionation schedule for locally advanced breast cancer. Pigott, K., Dische, S., Saunders, M.I. The British journal of radiology. (1995) [Pubmed]
  4. What is the lowest effective biologic dose for prophylactic cranial irradiation? Komaki, R., Byhardt, R.W., Anderson, T., Libnoch, J.A., Cox, J.D., Hansen, R., Holoye, P.Y. Am. J. Clin. Oncol. (1985) [Pubmed]
  5. LDR vs. HDR brachytherapy for localized prostate cancer: the view from radiobiological models. King, C.R. Brachytherapy. (2002) [Pubmed]
  6. Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse. Russell, W.L., Kelly, E.M., Hunsicker, P.R., Bangham, J.W., Maddux, S.C., Phipps, E.L. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  7. Effect of cycloheximide or puromycin on induction of thermotolerance by heat in Chinese hamster ovary cells: dose fractionation at 45.5 degrees C1. Lee, Y.J., Dewey, W.C. Cancer Res. (1987) [Pubmed]
  8. Effect of dose fractionation of daunorubicin on survival of leukemic cells. Razek, A., Valeriote, F., Vietti, T. Cancer Res. (1980) [Pubmed]
  9. Pharmacodynamics of gemifloxacin against Streptococcus pneumoniae in an in vitro pharmacokinetic model of infection. MacGowan, A.P., Rogers, C.A., Holt, H.A., Wootton, M., Bowker, K.E. Antimicrob. Agents Chemother. (2001) [Pubmed]
  10. Pharmacodynamics of fluconazole in a murine model of systemic candidiasis. Louie, A., Drusano, G.L., Banerjee, P., Liu, Q.F., Liu, W., Kaw, P., Shayegani, M., Taber, H., Miller, M.H. Antimicrob. Agents Chemother. (1998) [Pubmed]
  11. Modification of radiation-induced damage to bone marrow stem cells by dose rate, dose fractionation, and prior exposure to cytoxan as judged by the survival of CFUs: application to bone marrow transplantation (BMT). Evans, R.G., Wheatley, C.L., Nielsen, J.R. Int. J. Radiat. Oncol. Biol. Phys. (1988) [Pubmed]
  12. Dose-rate effects in mammalian cells: V. Dose fractionation effects in noncycling C3H 10T 1/2 cells. Zeman, E.M., Bedford, J.S. Int. J. Radiat. Oncol. Biol. Phys. (1984) [Pubmed]
  13. The effect of dose fractionation on the frequency of ethylnitrosourea-induced dominant cataract and recessive specific locus mutations in germ cells of the mouse. Favor, J., Neuhäuser-Klaus, A., Ehling, U.H. Mutat. Res. (1988) [Pubmed]
  14. In vivo radiosensitizing activity of a new fluorinated hypoxic cell radiosensitizer, KU-2285, in combination with radiation dose fractionation. Sasai, K., Fushiki, M., Yukawa, Y., Suyama, S., Iwai, H., Shibamoto, Y., Nishimoto, S., Takahashi, M., Abe, M. Int. J. Radiat. Oncol. Biol. Phys. (1991) [Pubmed]
  15. Epirubicin and ifosfamide in metastatic breast cancer. Becher, R., Kloke, O., Hayungs, J., Hartwich, G., Bartels, H., Szanto, J., Wolf, E., Illiger, H.J., Halabi, S., Rieche, K., Hering, K.G., Ohl, S., DeDycker, R., Huhn, R., Fischedick, A.R., Höfeler, H., Pielken, H.J., Hawig, I., Hirche, H., Seeber, S. Semin. Oncol. (1996) [Pubmed]
  16. Interaction between the microtubule inhibitor tubulozole and gamma-irradiation in murine tumors in vivo. Distelmans, W., Van Ginckel, R., Vanherck, W., Willebrords, R., De Brabander, M., Wouters, L., Van den Winkel, P., De Backer, G. Int. J. Radiat. Oncol. Biol. Phys. (1989) [Pubmed]
  17. Caffeine-induced apoptosis reveals a persistent lesion after treatment with bromodeoxyuridine and ultraviolet-B light. Hagan, M.P., Hopcia, K.L., Sylvester, F.C., Held, K.D. Radiat. Res. (1997) [Pubmed]
  18. Comparing and combining light dose fractionation and iron chelation to enhance experimental photodynamic therapy with aminolevulinic acid. Curnow, A., Macrobert, A.J., Bown, S.G. Lasers in surgery and medicine. (2006) [Pubmed]
  19. Recovery after exposure to near-ultraviolet light of cells containing 5-bromodeoxyuridine. Hagan, M.P., Elkind, M.M. Biophys. J. (1981) [Pubmed]
  20. Evaluation of the ECAT EXACT HR+ 3-D PET scanner in H2(15)O brain activation studies: dose fractionation strategies for rCBF and signal enhancing protocols. Moreno-Cantú, J.J., Thompson, C.J., Zatorre, R.J. IEEE transactions on medical imaging. (1998) [Pubmed]
  21. The severity of late rectal and recto-sigmoid complications related to fraction size in irradiation treatment of carcinoma cervix stage III B. Deore, S.M., Shrivastava, S.K., Viswanathan, P.S., Dinshaw, K.A. Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]. (1991) [Pubmed]
  22. Nicotinamide as a repair inhibitor in vivo: studies using single and fractionated X-ray doses in mouse skin and kidneys. Rojas, A., Denekamp, J., Johns, H., Kjellen, E., Tsang, R., Nilsson, P., Stratford, M.R., Dennis, M.F., Joiner, M.C. Radiat. Res. (1996) [Pubmed]
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