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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Estrogen-induced hyperkeratosis of the nipple.

Hyperkeratosis of the nipple and areola has been classically divided into three categories: a part of an epidermal nevus, a type associated with ichthyosis, and a nevoid form seen in young women. A case of hyperkeratosis of the nipples in a patient with adenocarcinoma of the prostate treated with diethylstilbestrol is described herein. A possible correlation between estrogens and an acquired form of this rare skin disorder is suggested.[1]


  1. Estrogen-induced hyperkeratosis of the nipple. Mold, D.E., Jegasothy, B.V. Cutis; cutaneous medicine for the practitioner. (1980) [Pubmed]
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