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Smith, P.R.

The effect of cismethrin on the rat dorsal root potentials.

Dorsal root potentials were recorded from urethane-anaesthetised rats. Bicuculline, a recognised GABA antagonist, reduced the amplitude of the potential to 67% of control. Cismethrin, a synthetic pyrethroid insecticide, enhanced the potential to 142% of control values. The convulsions associated with cismethrin poisoning therefore are not produced by an antagonism of GABA-mediated inhibitory transmission.[1]

References

The effect of cismethrin on the rat dorsal root potentials. Smith, P.R. Eur. J. Pharmacol. (1980) [Pubmed]

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