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Chemical Compound Review

SureCN5933797     (5-benzyl-2-furyl)methyl (1S,3S)-2,2...

Synonyms: AC1L1XDO, LS-58678, AC1Q6696
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Disease relevance of NRDC 119

  • Values for blood flow in the cortical regions were remarkably similar to those found in rats showing symptoms typical of the type-1 syndrome of pyrethroid toxicity ie. tremors and heightened startle response induced with cismethrin [1].
  • The Type I pyrethroid, cismethrin (15 mg/kg, po), produced a 17% reduction in the threshold dosage of ip-PTZ required to induce a seizure, while delaying the onset of generalized seizure activity [2].

Psychiatry related information on NRDC 119

  • The time course of onset and recovery for this decreased activity was rapid (1 to 4 hr) No cumulative effects on motor activity of a 30-day exposure to 2 mg/kg/day deltamethrin or 6 mg/kg/day cismethrin were found [3].

High impact information on NRDC 119


Biological context of NRDC 119


Anatomical context of NRDC 119


Gene context of NRDC 119

  • Cismethrin, a pyrethroid that produces Type I effects on intact nerve, slowed the inactivation of sodium currents carried by Vssc1/tipE channels during a depolarizing pulse and induced a tail current after repolarization that decayed with a first-order time constant of approximately 650 ms [10].


  1. Changes in regional cerebral blood flow and glucose metabolism associated with symptoms of pyrethroid toxicity. Cremer, J.E., Seville, M.P. Neurotoxicology (1985) [Pubmed]
  2. An examination of the proconvulsant actions of pyrethroid insecticides using pentylenetetrazol and amygdala kindling seizure models. Gilbert, M.E., Acheson, S.K., Mack, C.M., Crofton, K.M. Neurotoxicology (1990) [Pubmed]
  3. Effects of two pyrethroid insecticides on motor activity and the acoustic startle response in the rat. Crofton, K.M., Reiter, L.W. Toxicol. Appl. Pharmacol. (1984) [Pubmed]
  4. Pyrethroid insecticides and DDT modify alkaloid-dependent sodium channel activation and its enhancement by sea anemone toxin. Bloomquist, J.R., Soderlund, D.M. Mol. Pharmacol. (1988) [Pubmed]
  5. The role of basal forebrain in the primary cholinergic vasodilation in rat neocortex produced by systemic administration of cismethrin. Lister, T., Ray, D.E. Brain Res. (1988) [Pubmed]
  6. Point mutations in homology domain II modify the sensitivity of rat Nav1.8 sodium channels to the pyrethroid insecticide cismethrin. Soderlun, D.M., Lee, S.H. Neurotoxicology (2001) [Pubmed]
  7. In vitro covalent binding of cismethrin, bioresmethrin, and their common alcohol to hepatic proteins. Hoellinger, H., Sonnier, M., Gray, A.J., Connors, T.A., Pichon, J., Nguyen, H.N. Toxicol. Appl. Pharmacol. (1985) [Pubmed]
  8. The effect of cismethrin on the rat dorsal root potentials. Smith, P.R. Eur. J. Pharmacol. (1980) [Pubmed]
  9. Pharmacological effects of pyrethroids on the cardiovascular system of the rat. Forshaw, P.J., Bradbury, J.E. Eur. J. Pharmacol. (1983) [Pubmed]
  10. Actions of the pyrethroid insecticides cismethrin and cypermethrin on house fly Vssc1 sodium channels expressed in Xenopus oocytes. Smith, T.J., Ingles, P.J., Soderlund, D.M. Arch. Insect Biochem. Physiol. (1998) [Pubmed]
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