Disease relevance of NRDC 119

• Values for blood flow in the cortical regions were remarkably similar to those found in rats showing symptoms typical of the type-1 syndrome of pyrethroid toxicity ie. tremors and heightened startle response induced with cismethrin [1].
• The Type I pyrethroid, cismethrin (15 mg/kg, po), produced a 17% reduction in the threshold dosage of ip-PTZ required to induce a seizure, while delaying the onset of generalized seizure activity [2].

Psychiatry related information on NRDC 119

• The time course of onset and recovery for this decreased activity was rapid (1 to 4 hr) No cumulative effects on motor activity of a 30-day exposure to 2 mg/kg/day deltamethrin or 6 mg/kg/day cismethrin were found [3].

High impact information on NRDC 119

• The effects of saturating concentrations of DDT [1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane] and the pyrethroid insecticides cismethrin and deltamethrin on alkaloid-dependent activation of the voltage-sensitive sodium channel were studied using measurements of 22Na+ uptake into mouse brain synaptosomes [4].
• Mutually exclusive effects on veratridine-dependent uptake were observed when cismethrin was co-applied with ATX II [4].
• The role of basal forebrain in the primary cholinergic vasodilation in rat neocortex produced by systemic administration of cismethrin [5].
• Systemic cismethrin is thus capable of activating a cholinergic vasodilation in the cortex and, in the parietal cortex at least, a substantial proportion of the flow increase is mediated by extrinsic projections from the basal forebrain [5].
• The pyrethroid insecticide cismethrin (9 mumol/kg) causes a large blood flow increase in cerebral cortex, without a parallel increase in metabolism [5].

Biological context of NRDC 119

• Point mutations in homology domain II modify the sensitivity of rat Nav1.8 sodium channels to the pyrethroid insecticide cismethrin [6].

Anatomical context of NRDC 119

• Inversely, when microsomes were used more covalent binding occurred with bioresmethrin and BFA than with cismethrin [7].
• The effect of cismethrin on the rat dorsal root potentials [8].
• The cardiovascular actions of two pyrethroids, deltamethrin and cismethrin, were assessed using the pithed rat, the isolated working heart, and perfused mesentery preparations [9].
• Actions of the pyrethroid insecticides cismethrin and cypermethrin on house fly Vssc1 sodium channels expressed in Xenopus oocytes [10].

Gene context of NRDC 119

• Cismethrin, a pyrethroid that produces Type I effects on intact nerve, slowed the inactivation of sodium currents carried by Vssc1/tipE channels during a depolarizing pulse and induced a tail current after repolarization that decayed with a first-order time constant of approximately 650 ms [10].

References