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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Genetic predisposition to febrile convulsions: a preliminary study.

The participation of genetic factors in the origin of convulsive disorders is a controversial matter. In an attempt to study the influence of heredity in a selected group of patients, we evaluated 128 subjects that presented febrile febrile convulsions. Of these, 18 (14,3% of the sample) had at least one relative affected by the same problem. Even though a more definite conclusion depends on sample enlargement and on setting up a control group, pedigree observation suggests the participation of an autosomal dominant gene, with incomplete and probably low penetrance, in the etiology of febrile convulsions.[1]


  1. Genetic predisposition to febrile convulsions: a preliminary study. Raffin, C.N., Giugliani, R., Armbrust-Figueiredo, J. Arquivos de neuro-psiquiatria. (1980) [Pubmed]
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