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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Functional expression of the renal organic cation transporter and P-glycoprotein in Xenopus laevis oocytes.

The hypothesis that P-glycoprotein ( P-gp) mediates the renal secretion of organic cations was tested by functional expression of mRNAs in the Xenopus laevis oocyte system. Efflux of 2'-deoxytubercidin (dTub), a substrate for the renal organic cation transporter ( OCT) but not for P-gp, was enhanced by injection of renal mRNA but not by injection of mRNA from P-gp-overexpressing cells (MDCK cells transduced with the cDNA for human MDR1). The functional capacity of the MDCK-MDR mRNA was established by its ability to reduce the steady-state uptake of a classical P-gp substrate, vinblastine. Thus, these data indicate OCT and P-gp to be distinct entities. The Xenopus oocyte system provides a functional approach to further characterize the OCT.[1]

References

  1. Functional expression of the renal organic cation transporter and P-glycoprotein in Xenopus laevis oocytes. Nelson, J.A., Dutt, A., Allen, L.H., Wright, D.A. Cancer Chemother. Pharmacol. (1995) [Pubmed]
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