Signalling downstream of activated mammalian Notch.
Notch belongs to a family of transmembrane proteins that are widely conserved from flies to vertebrates and are thought to be involved in cell-fate decisions. In Drosophila, the Suppressor of hairless (Su(H)) gene and genes of the Enhancer of split (E(Spl)) complex, which encode proteins of the basic helix-loop-helix type have been implicated in the Notch signalling pathway. Mammalian homologues of E(Spl), such as the mouse Hairy enhancer of split (HES-1), have been isolated. Both HES-1 and the intracellular domain of murine Notch (mNotch) are able to block MyoD-induced myogenesis. Here we show that activated forms of mNotch associate with the human analogue of Su(H), KBF2/ RBP-J kappa (refs 8,9) and act as transcriptional activators through the KBF2- binding sites of the HES-1 promoter.[1]References
- Signalling downstream of activated mammalian Notch. Jarriault, S., Brou, C., Logeat, F., Schroeter, E.H., Kopan, R., Israel, A. Nature (1995) [Pubmed]
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