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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Circadian expression of transcription factor Fra-2 in the rat pineal gland.

Physiological changes in Fos-like immunoreactivity in the rat pineal gland are shown here to be due primarily to changes in a 42/46-kDa Fos-related antigen ( Fra). Studies are presented that indicate this 42/46-kDa Fra is Fra-2, a poorly understood member of the Fos family of transcription factors. Both Fra-2 mRNA and protein are absent during the day and increase robustly at night on a circadian basis; organ culture studies indicate that regulation is mediated by an adrenergic-->cyclic AMP mechanism. AP-1 binding activity changes in parallel to changes in the level of Fra-2 protein.[1]

References

  1. Circadian expression of transcription factor Fra-2 in the rat pineal gland. Baler, R., Klein, D.C. J. Biol. Chem. (1995) [Pubmed]
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