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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta T cells.

In T-cell precursors, the T-cell-receptor beta chain is expressed before the T-cell-receptor alpha chain and is sufficient to advance T-cell development in the absence of T-cell receptor alpha chains. In immature T cells, the T-cell-receptor beta protein can form disulphide-linked heterodimers with the pre-T-cell-receptor alpha chain and associate with signal-transducing CD3 molecules. The recently cloned pre-T-cell-receptor alpha gene encodes a transmembrane protein that is expressed in immature but not mature T cells. Here we show that alpha beta, but not gamma delta, cell development is severely hampered in pre-T-cell-receptor alpha-gene-deficient mice, which establishes a crucial role for the pre-T-cell receptor in early thymocyte development.[1]

References

  1. Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta T cells. Fehling, H.J., Krotkova, A., Saint-Ruf, C., von Boehmer, H. Nature (1995) [Pubmed]
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