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Gene Review

Tcra  -  T cell receptor alpha chain

Mus musculus

Synonyms: T-cell receptor alpha chain C region, Tcr alpha, Tcralpha
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Disease relevance of Tcra


High impact information on Tcra


Chemical compound and disease context of Tcra


Biological context of Tcra

  • We propose that the array of V alpha genes in various Tcra haplotypes exerts influence over the proportion of CD4 and CD8 subsets generated and may account in part for the observed thymic skewing [11].
  • Here, we have shown that polymorphism in CD4/CD8 skewing between B6 and BALB/c mice is determined by the stem cell genotype and not by environmental effects, and that it maps in or near the TCR alpha-chain complex, Tcra [11].
  • The resulting congenic line, B10.D2.C-Tcraa/Bo carries a recombination between the Tcra and the hr loci; thus, the transferred differential segment is the centromeric 18-27 cM of the BALB/c chromosome 14 [12].
  • Recent studies have demonstrated that the diversity of T-cell receptor alpha (Tcra) gene expression may be confined by a developmental program for gene rearrangement [13].
  • RFLP analysis of the Rib-1 locus, located in close proximity to the Tcra locus on chromosome 14, showed that B10.A(18R) carries the Rib-1b allele from B10 [14].

Anatomical context of Tcra

  • Assembly of the gene encoding T cell receptor alpha (Tcra) is characterized by an orderly progression of primary and secondary V(alpha)-to-J(alpha) recombination events across the J(alpha) array, but the targeting mechanisms responsible for this progression are mostly unknown [15].
  • The mouse Supt16h/Fact140 gene, encoding part of the FACT chromatin transcription complex, maps close to Tcra and is highly expressed in thymus [16].
  • Using the human cell line SUP-T1, bearing the inversion inv(14) (q11;q32), we further demonstrated the loci order in man to be centromere-NP-1-Tcr alpha-CTLA-1 [17].
  • The effect of the Tcra haplotype on V alpha 2 epitope expression was evident not only among lymph node T cells but also among mature, cortisone-resistant thymocytes [18].
  • Segregation analysis of somatic cell hybrids demonstrates that in both patients the breakpoints occur between the variable (V) and constant (C) region genes of the T-cell receptor alpha-chain locus, resulting in the translocation of the C-region gene from chromosome 14 to chromosome 11 [19].

Associations of Tcra with chemical compounds


Physical interactions of Tcra


Regulatory relationships of Tcra


Other interactions of Tcra

  • One of these haplotypes (Tcre alpha) appears to arise from a recombination between the Tcrb alpha and Tcra alpha haplotypes, the latter being the most frequently found in the conventional inbred strains [24].
  • A similar exon/intron structure encoding corresponding parts of the mature polypeptide is found both in the Tcra and Tcrd constant region genes [25].
  • The distribution of the genes along the Tcra locus, plus their structural organization, indicates that successive duplications occurred during the processes of expansion and contraction of the Tcra-V gene subfamilies [26].
  • Two genes, Np-1 and Tcra, which fail to recombine in crosses involving conventional strains of mice, were shown to recombine readily in interspecific crosses involving Mus spretus [27].
  • Alteration of interleukin 4 production results in the inhibition of T helper type 2 cell-dominated inflammatory bowel disease in T cell receptor alpha chain-deficient mice [1].

Analytical, diagnostic and therapeutic context of Tcra


  1. Alteration of interleukin 4 production results in the inhibition of T helper type 2 cell-dominated inflammatory bowel disease in T cell receptor alpha chain-deficient mice. Iijima, H., Takahashi, I., Kishi, D., Kim, J.K., Kawano, S., Hori, M., Kiyono, H. J. Exp. Med. (1999) [Pubmed]
  2. RAG-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice. Petiniot, L.K., Weaver, Z., Vacchio, M., Shen, R., Wangsa, D., Barlow, C., Eckhaus, M., Steinberg, S.M., Wynshaw-Boris, A., Ried, T., Hodes, R.J. Mol. Cell. Biol. (2002) [Pubmed]
  3. Susceptibility to Coxsackievirus B3-induced chronic myocarditis maps near the murine Tcr alpha and Myhc alpha loci on chromosome 14. Traystman, M.D., Chow, L.H., McManus, B.M., Herskowitz, A., Nesbitt, M.N., Beisel, K.W. Am. J. Pathol. (1991) [Pubmed]
  4. Development of colitis in signal transducers and activators of transcription 6-deficient T-cell receptor alpha-deficient mice: a potential role of signal transducers and activators of transcription 6-independent interleukin-4 signaling for the generation of Th2-biased pathological CD4+ betabetaT cells. Okuda, Y., Takahashi, I., Kim, J.K., Ohta, N., Iwatani, K., Iijima, H., Kai, Y., Tamagawa, H., Hiroi, T., Kweon, M.N., Kawano, S., Takeda, K., Akira, S., Sasaki, Y., Hori, M., Kiyono, H. Am. J. Pathol. (2003) [Pubmed]
  5. CD1d function is regulated by microsomal triglyceride transfer protein. Brozovic, S., Nagaishi, T., Yoshida, M., Betz, S., Salas, A., Chen, D., Kaser, A., Glickman, J., Kuo, T., Little, A., Morrison, J., Corazza, N., Kim, J.Y., Colgan, S.P., Young, S.G., Exley, M., Blumberg, R.S. Nat. Med. (2004) [Pubmed]
  6. Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta T cells. Fehling, H.J., Krotkova, A., Saint-Ruf, C., von Boehmer, H. Nature (1995) [Pubmed]
  7. Isolation of an excision product of T-cell receptor alpha-chain gene rearrangements. Fujimoto, S., Yamagishi, H. Nature (1987) [Pubmed]
  8. The gene encoding the T-cell receptor alpha-chain maps close to the Np-2 locus on mouse chromosome 14. Dembić, Z., Bannwarth, W., Taylor, B.A., Steinmetz, M. Nature (1985) [Pubmed]
  9. Susceptibility of T cell receptor-alpha chain knock-out mice to ultraviolet B light and fluorouracil: a novel model for drug-induced cutaneous lupus erythematosus. Yoshimasu, T., Nishide, T., Seo, N., Hiroi, A., Ohtani, T., Uede, K., Furukawa, F. Clin. Exp. Immunol. (2004) [Pubmed]
  10. Cloning of an unidentified T-cell receptor alpha chain gene from a vesicular stomatitis virus-specific helper T-cell clone. Ghelardi, E., Burkhart, C., Senesi, S., Hengartner, H., Freer, G. Immunol. Lett. (1996) [Pubmed]
  11. Thymic skewing of the CD4/CD8 ratio maps with the T-cell receptor alpha-chain locus. Sim, B.C., Aftahi, N., Reilly, C., Bogen, B., Schwartz, R.H., Gascoigne, N.R., Lo, D. Curr. Biol. (1998) [Pubmed]
  12. A Tcra congenic mouse: V alpha epitope expression is influenced by both Tcra haplotypes and background genes. Gleditsch, L., Bogen, B. Immunogenetics (1992) [Pubmed]
  13. Diversity of T-cell receptor alpha gene transcripts in the newborn and adult periphery. Thompson, S.D., Larché, M., Manzo, A.R., Hurwitz, J.L. Immunogenetics (1992) [Pubmed]
  14. Chromosome 14 in B10.A(18R) mice is recombinant and includes Tcra-Va alleles. Nakajima, P.B., Di Vincenzo, J.P., Jameson, S.C., Gascoigne, N.R. Immunogenetics (1992) [Pubmed]
  15. Regulation of T cell receptor alpha gene assembly by a complex hierarchy of germline Jalpha promoters. Hawwari, A., Bock, C., Krangel, M.S. Nat. Immunol. (2005) [Pubmed]
  16. The mouse Supt16h/Fact140 gene, encoding part of the FACT chromatin transcription complex, maps close to Tcra and is highly expressed in thymus. McGuire, M.V., Suthipinijtham, P., Gascoigne, N.R. Mamm. Genome (2001) [Pubmed]
  17. Proximity of the CTLA-1 serine esterase and Tcr alpha loci in mouse and man. Harper, K., Mattéi, M.G., Simon, D., Suzan, M., Guénet, J.L., Haddad, P., Sasportes, M., Golstein, P. Immunogenetics (1988) [Pubmed]
  18. T-cell receptor alpha haplotype influences V alpha epitope expression on both cortisone-resistant thymocytes and lymph node T cells. Bogen, B., Gleditsch, L., Teig, A. Scand. J. Immunol. (1993) [Pubmed]
  19. Breakpoints in the human T-cell antigen receptor alpha-chain locus in two T-cell leukaemia patients with chromosomal translocations. Lewis, W.H., Michalopoulos, E.E., Williams, D.L., Minden, M.D., Mak, T.W. Nature (1985) [Pubmed]
  20. Influence of the NH2-terminal amino acid of the T cell receptor alpha chain on major histocompatibility complex (MHC) class II + peptide recognition. Seibel, J.L., Wilson, N., Kozono, H., Marrack, P., Kappler, J.W. J. Exp. Med. (1997) [Pubmed]
  21. A new mouse T-cell receptor alpha chain variable region family. Sutherland, R.M., Paterson, Y., Scherle, P.A., Gerhard, W., Caton, A.J. Immunogenetics (1991) [Pubmed]
  22. Major histocompatibility complex determinants select T-cell receptor alpha chain variable region dominance in a peptide-specific response. Natarajan, K., Burstyn, D., Zauderer, M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  23. T cell receptor alpha-chain influences reactivity to Mls-1 in V beta 8.1 transgenic mice. Smith, H.P., Le, P., Woodland, D.L., Blackman, M.A. J. Immunol. (1992) [Pubmed]
  24. Complexity, polymorphism, and recombination of mouse T-cell receptor alpha gene families. Jouvin-Marche, E., Morgado, M.G., Trede, N., Marche, P.N., Couez, D., Hue, I., Gris, C., Malissen, M., Cazenave, P.A. Immunogenetics (1989) [Pubmed]
  25. Genomic structure and chromosomal location of the mouse pre-T-cell receptor alpha gene. Fehling, H.J., Laplace, C., Mattei, M.G., Saint-Ruf, C., von Boehmer, H. Immunogenetics (1995) [Pubmed]
  26. Germline genomic structure of the B10.A mouse Tcra-V2 gene subfamily. Gahéry-Ségard, H., Jouvin-Marche, E., Six, A., Gris-Liebe, C., Malissen, M., Malissen, B., Cazenave, P.A., Marche, P.N. Immunogenetics (1996) [Pubmed]
  27. A complex of serine protease genes expressed preferentially in cytotoxic T-lymphocytes is closely linked to the T-cell receptor alpha- and delta-chain genes on mouse chromosome 14. Crosby, J.L., Bleackley, R.C., Nadeau, J.H. Genomics (1990) [Pubmed]
  28. Evaluation of the percentage of peripheral T cells with two different T cell receptor alpha-chains and of their potential role in autoimmunity. Corthay, A., Nandakumar, K.S., Holmdahl, R. J. Autoimmun. (2001) [Pubmed]
  29. Two distinct T-cell receptor alpha-chain transcripts in a rabbit T-cell line: implications for allelic exclusion in T cells. Marche, P.N., Kindt, T.J. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  30. Antigen-specific immunoregulatory activity of a T cell receptor alpha chain generated by expression PCR. Onda, T., Messier, H., Bissonette, R., Echeverri, F., Baier, G., Fotedar, A., Green, D.R. Int. Arch. Allergy Immunol. (1995) [Pubmed]
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