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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Genomic organization of a mouse type I activin receptor.

We have characterized the genomic organization of a mouse type I activin receptor. Using the mouse tsk7L cDNA, 4 overlapping lambda clones containing the activin receptor IA (ActRIA) gene were isolated from a mouse 129 Sv genomic library. The mouse ActRIA gene is encoded by 10 exons and spans approximately 40 kb. The size of the introns was determined and the intron/exon boundaries were sequenced. Primer extension analysis of the 5' non-translated region using RNA from different organs or tissues revealed a strong transcription start site 68 nucleotides upstream of the ATG. Knowledge of the structure of the ActRIA gene is essential for the production of ActRIA deficient mice by homologous recombination.[1]


  1. Genomic organization of a mouse type I activin receptor. Schmitt, J., Mielke, R., Schrewe, H. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
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