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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Molecular cloning and expression of subunit 12: a non-MCP and non-ATPase subunit of the 26 S protease.

A cDNA encoding subunit 12 ( S12) of human erythrocyte 26 S protease has been isolated, sequenced and expressed. The cDNA contains an open reading frame that encodes a 36.6 kDA protein 96% identical to mouse Mov-34 and 67% identical to its Drosophila melanogaster homolog. Based on the high degree of sequence identity between human S12, mouse and Drosophila Mov-34 proteins, we conclude that the Mov-34 gene product is a component of the 26 S protease. Antibodies produced against two S12 fragments, Met1-Tyr95 (S12f95) and Met1-Leu205 (S12f205), react with S12 transferred to nitrocellulose from SDS-PAGE. In contrast, after transfer from native gels, the epitope(s) recognized by anti-S12f205 is exposed in the regulatory complex but appears to be masked when the regulatory complex associates with the multicatalytic protease.[1]

References

  1. Molecular cloning and expression of subunit 12: a non-MCP and non-ATPase subunit of the 26 S protease. Dubiel, W., Ferrell, K., Dumdey, R., Standera, S., Prehn, S., Rechsteiner, M. FEBS Lett. (1995) [Pubmed]
 
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