Regulators of cell death.
A novel oncogene-derived protein, Bcl-2, functions as a repressor of cell death in a genetic pathway of cellular suicide that appears to be common to all multicellular animals. A related protein that promotes cell death, Bax, wrestles with Bcl-2 through conserved motifs, BH1 and BH2, establishing a set point for these deaths. In Bcl-2-deficient mice, the ratio of these molecules is reset, resulting in massive cell death in several cell types.[1]References
- Regulators of cell death. Korsmeyer, S.J. Trends Genet. (1995) [Pubmed]
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