Gene Review:
Bcl2 - B cell leukemia/lymphoma 2
Mus musculus
Synonyms:
AW986256, Apoptosis regulator Bcl-2, Bcl-2, C430015F12Rik, D630044D05Rik, ...
Einat,
Yuan,
Manji,
Villunger,
Marsden,
Zhan,
Erlacher,
Lew,
Bouillet,
Berzins,
Godfrey,
Heath,
Strasser,
Chernigovskaya,
Taranukhin,
Glazova,
Yamova,
Fedorov,
Einat,
Manji,
Hotchkiss,
Chang,
Swanson,
Tinsley,
Hui,
Klender,
Xanthoudakis,
Roy,
Black,
Grimm,
Aspiotis,
Han,
Nicholson,
Karl,
Zhang,
Shi,
Zhang,
- Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. McGill, G.G., Horstmann, M., Widlund, H.R., Du, J., Motyckova, G., Nishimura, E.K., Lin, Y.L., Ramaswamy, S., Avery, W., Ding, H.F., Jordan, S.A., Jackson, I.J., Korsmeyer, S.J., Golub, T.R., Fisher, D.E. Cell (2002)
- An early and massive wave of germinal cell apoptosis is required for the development of functional spermatogenesis. Rodriguez, I., Ody, C., Araki, K., Garcia, I., Vassalli, P. EMBO J. (1997)
- Bim is a suppressor of Myc-induced mouse B cell leukemia. Egle, A., Harris, A.W., Bouillet, P., Cory, S. Proc. Natl. Acad. Sci. U.S.A. (2004)
- VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia. Egle, A., Harris, A.W., Bath, M.L., O'Reilly, L., Cory, S. Blood (2004)
- Differential expression of proteins of caspases and Bcl-2 families in the brain of mice. Min, S.H., Hwang, D.Y., Kang, T.S., Hwang, J.H., Lim, C.H., Lee, S.H., Lim, H.J., Seo, S.J., Sheen, Y.Y., Paik, S.G., Cho, J.S., Kim, Y.K. Int. J. Mol. Med. (2003)
- Cellular plasticity cascades: genes-to-behavior pathways in animal models of bipolar disorder. Einat, H., Manji, H.K. Biol. Psychiatry (2006)
- Sequential activation of individual caspases, and of alterations in Bcl-2 proapoptotic signals in a mouse model of Huntington's disease. Zhang, Y., Ona, V.O., Li, M., Drozda, M., Dubois-Dauphin, M., Przedborski, S., Ferrante, R.J., Friedlander, R.M. J. Neurochem. (2003)
- Increased anxiety-like behaviors and mitochondrial dysfunction in mice with targeted mutation of the Bcl-2 gene: further support for the involvement of mitochondrial function in anxiety disorders. Einat, H., Yuan, P., Manji, H.K. Behav. Brain Res. (2005)
- Apoptotic signaling proteins: possible participation in the regulation of vasopressin and catecholamines biosynthesis in the hypothalamus. Chernigovskaya, E.V., Taranukhin, A.G., Glazova, M.V., Yamova, L.A., Fedorov, L.M. Histochem. Cell Biol. (2005)
- Regulation of lymphocyte survival by the bcl-2 gene family. Cory, S. Annu. Rev. Immunol. (1995)
- Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death. Coultas, L., Bouillet, P., Stanley, E.G., Brodnicki, T.C., Adams, J.M., Strasser, A. Mol. Cell. Biol. (2004)
- Endogenously produced ganglioside GM3 endows etoposide and doxorubicin resistance by up-regulating Bcl-2 expression in 3LL Lewis lung carcinoma cells. Noguchi, M., Kabayama, K., Uemura, S., Kang, B.W., Saito, M., Igarashi, Y., Inokuchi, J. Glycobiology (2006)
- Bcl-2 inhibits gut epithelial apoptosis induced by acute lung injury in mice but has no effect on survival. Husain, K.D., Stromberg, P.E., Javadi, P., Buchman, T.G., Karl, I.E., Hotchkiss, R.S., Coopersmith, C.M. Shock (2003)
- The effect of Bcl-2 adenovirus against murine hepatocyte apoptosis caused by tumor necrosis factor alpha and D-galactosamine. Zhang, B., Zhang, D., Ren, H., Ma, Y. Zhonghua Gan Zang Bing Za Zhi (2001)
- Characterization of Apt- cell lines exhibiting cross-resistance to glucocorticoid- and Fas-mediated apoptosis. Askew, D.J., Kuscuoglu, U., Brunner, T., Green, D.R., Miesfeld, R.L. Cell Death Differ. (1999)
- Mouse models of cell death. Ranger, A.M., Malynn, B.A., Korsmeyer, S.J. Nat. Genet. (2001)
- A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Schmitt, C.A., Fridman, J.S., Yang, M., Lee, S., Baranov, E., Hoffman, R.M., Lowe, S.W. Cell (2002)
- B cell-specific transgenic expression of Bcl2 rescues early B lymphopoiesis but not B cell responses in BOB.1/OBF.1-deficient mice. Brunner, C., Marinkovic, D., Klein, J., Samardzic, T., Nitschke, L., Wirth, T. J. Exp. Med. (2003)
- Cyclin D1 is an essential mediator of apoptotic neuronal cell death. Kranenburg, O., van der Eb, A.J., Zantema, A. EMBO J. (1996)
- Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases. Deng, X., Ruvolo, P., Carr, B., May, W.S. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Bcl2 retards G1/S cell cycle transition by regulating intracellular ROS. Deng, X., Gao, F., May, W.S. Blood (2003)
- Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A. Deng, X., Ito, T., Carr, B., Mumby, M., May, W.S. J. Biol. Chem. (1998)
- Retinoid x receptor agonists increase bcl2a1 expression and decrease apoptosis of naive T lymphocytes. Rasooly, R., Schuster, G.U., Gregg, J.P., Xiao, J.H., Chandraratna, R.A., Stephensen, C.B. J. Immunol. (2005)
- Novel role for JNK as a stress-activated Bcl2 kinase. Deng, X., Xiao, L., Lang, W., Gao, F., Ruvolo, P., May, W.S. J. Biol. Chem. (2001)
- Activation of mitochondrial ATP-dependent potassium channels protects neurons against ischemia-induced death by a mechanism involving suppression of Bax translocation and cytochrome c release. Liu, D., Lu, C., Wan, R., Auyeung, W.W., Mattson, M.P. J. Cereb. Blood Flow Metab. (2002)
- Soy processing influences growth of estrogen-dependent breast cancer tumors. Allred, C.D., Allred, K.F., Ju, Y.H., Goeppinger, T.S., Doerge, D.R., Helferich, W.G. Carcinogenesis (2004)
- BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Zong, W.X., Lindsten, T., Ross, A.J., MacGregor, G.R., Thompson, C.B. Genes Dev. (2001)
- Membrane-associated CD19-LYN complex is an endogenous p53-independent and Bc1-2-independent regulator of apoptosis in human B-lineage lymphoma cells. Myers, D.E., Jun, X., Waddick, K.G., Forsyth, C., Chelstrom, L.M., Gunther, R.L., Tumer, N.E., Bolen, J., Uckun, F.M. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist. Hegde, R., Srinivasula, S.M., Ahmad, M., Fernandes-Alnemri, T., Alnemri, E.S. J. Biol. Chem. (1998)
- Bag-1 and Bcl-2 gene transfer in malignant glioma: modulation of cell cycle regulation and apoptosis. Roth, W., Grimmel, C., Rieger, L., Strik, H., Takayama, S., Krajewski, S., Meyermann, R., Dichgans, J., Reed, J.C., Weller, M. Brain Pathol. (2000)
- Proapoptotic activity of ITM2B(s), a BH3-only protein induced upon IL-2-deprivation which interacts with Bcl-2. Fleischer, A., Ayllón, V., Dumoutier, L., Renauld, J.C., Rebollo, A. Oncogene (2002)
- S-allylcysteine, a water-soluble garlic derivative, suppresses the growth of a human androgen-independent prostate cancer xenograft, CWR22R, under in vivo conditions. Chu, Q., Lee, D.T., Tsao, S.W., Wang, X., Wong, Y.C. BJU Int. (2007)
- Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Yang, E., Zha, J., Jockel, J., Boise, L.H., Thompson, C.B., Korsmeyer, S.J. Cell (1995)
- Apoptotic protease activating factor 1 (Apaf-1)-independent cell death suppression by Bcl-2. Haraguchi, M., Torii, S., Matsuzawa, S., Xie, Z., Kitada, S., Krajewski, S., Yoshida, H., Mak, T.W., Reed, J.C. J. Exp. Med. (2000)
- Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling. Villunger, A., Marsden, V.S., Zhan, Y., Erlacher, M., Lew, A.M., Bouillet, P., Berzins, S., Godfrey, D.I., Heath, W.R., Strasser, A. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Bak but not Bax is essential for Bcl-xS-induced apoptosis. Lindenboim, L., Kringel, S., Braun, T., Borner, C., Stein, R. Cell Death Differ. (2005)
- Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Miyazaki, T., Liu, Z.J., Kawahara, A., Minami, Y., Yamada, K., Tsujimoto, Y., Barsoumian, E.L., Permutter, R.M., Taniguchi, T. Cell (1995)
- Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Akashi, K., Kondo, M., von Freeden-Jeffry, U., Murray, R., Weissman, I.L. Cell (1997)
- Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax. LeBlanc, H., Lawrence, D., Varfolomeev, E., Totpal, K., Morlan, J., Schow, P., Fong, S., Schwall, R., Sinicropi, D., Ashkenazi, A. Nat. Med. (2002)
- Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome. Marsden, V.S., O'Connor, L., O'Reilly, L.A., Silke, J., Metcalf, D., Ekert, P.G., Huang, D.C., Cecconi, F., Kuida, K., Tomaselli, K.J., Roy, S., Nicholson, D.W., Vaux, D.L., Bouillet, P., Adams, J.M., Strasser, A. Nature (2002)
- Expression of apoptosis regulatory proteins in tubular epithelium stressed in culture or following acute renal failure. Ortiz, A., Lorz, C., Catalán, M.P., Danoff, T.M., Yamasaki, Y., Egido, J., Neilson, E.G. Kidney Int. (2000)
- A murine ortholog of the human serpin SCCA2 maps to chromosome 1 and inhibits chymotrypsin-like serine proteinases. Bartuski, A.J., Kamachi, Y., Schick, C., Massa, H., Trask, B.J., Silverman, G.A. Genomics (1998)
- Maspin overexpression modulates tumor cell apoptosis through the regulation of Bcl-2 family proteins. Zhang, W., Shi, H.Y., Zhang, M. BMC Cancer (2005)
- Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte. Hotchkiss, R.S., Chang, K.C., Swanson, P.E., Tinsley, K.W., Hui, J.J., Klender, P., Xanthoudakis, S., Roy, S., Black, C., Grimm, E., Aspiotis, R., Han, Y., Nicholson, D.W., Karl, I.E. Nat. Immunol. (2000)
- Bcl-XL and Bcl-2 repress a common pathway of cell death. Chao, D.T., Linette, G.P., Boise, L.H., White, L.S., Thompson, C.B., Korsmeyer, S.J. J. Exp. Med. (1995)