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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Complete reconstitution of mouse liver with xenogeneic hepatocytes.

We have developed a system for studying hepatocellular growth potential in which liver cells are introduced into the diseased livers of albumin-urokinase ( Alb- uPA) transgenic mice. To use this system to study xenogeneic cell transplantation, rat liver cells were introduced into immunotolerant Alb- uPA transgenic mice. In regenerated recipient livers, up to 100% of hepatocellular gene expression was of rat origin, demonstrating the creation of a functional mouse liver in which parenchyma is derived from xenogeneic (rat) hepatocytes. Immunotolerant Alb- uPA transgenic mice provide a tool for studying hepatocellular biology of any species, including humans, in a controlled experimental setting.[1]


  1. Complete reconstitution of mouse liver with xenogeneic hepatocytes. Rhim, J.A., Sandgren, E.P., Palmiter, R.D., Brinster, R.L. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
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