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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The resistance of cellulases and xylanases to proteolytic inactivation.

The sensitivity of a range of cellulases and xylanases to proteolytic inactivation was investigated. The xylanases, all the Clostridium thermocellum cellulases and cellulase E from Pseudomonas fluorescens subsp. cellulosa exhibited no decrease in catalytic activity during a 3-h incubation with proteinases of the small intestine. Under these conditions, the control Escherichia coli enzymes analysed had half-lives of 4.3-13.5 min. The addition of substrate significantly decreased the sensitivity of proteinase-labile enzymes to inactivation. The significance of these data in relation to the use of cellulases and xylanases for improving animal nutrition is discussed.[1]


  1. The resistance of cellulases and xylanases to proteolytic inactivation. Fontes, C.M., Hall, J., Hirst, B.H., Hazlewood, G.P., Gilbert, H.J. Appl. Microbiol. Biotechnol. (1995) [Pubmed]
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