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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Differential inhibition by iodonium compounds of induced erythropoietin expression.

Diphenylene iodonium chloride suppresses the cobaltous chloride-induced expression of erythropoietin by Hep3B cells to about 50% at a concentration of 30 nM. At that concentration, it has no effect on the response to low oxygen. The related compound iodonium diphenyl chloride acts similarly but is a much less effective inhibitor. If, as reported, diphenylene iodonium chloride is a specific inhibitor of cytochrome b, it follows that the response to CoCl2 is dependent on that enzyme but the response to hypoxia is not.[1]


  1. Differential inhibition by iodonium compounds of induced erythropoietin expression. Goldwasser, E., Alibali, P., Gardner, A. J. Biol. Chem. (1995) [Pubmed]
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