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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The neuroprotective kappa-opioid CI-977 alters glutamate-induced calcium signaling in vitro.

The effect of the neuroprotective kappa opioid agonist CI-977 on glutamate (GLU)-stimulated calcium signaling was studied in individual primary rat cortical neurons. Using laser scanning confocal microscopy and the fluorescent calcium probe fluo-3, both the sustained and biphasic intracellular calcium concentration [Ca2+]i changes induced by GLU (20-40 microM) were altered by CI-977 (25-100 nM), thereby shifting the neuronal population response from unbuffered to buffered patterns of [Ca2+]i flux. This effect was consistent with the previously demonstrated neuroprotective action of CI-977 against glutamate toxicity in vitro. The effect of CI-977 in altering GLU-induced [Ca2+]i signaling was attenuated by naloxone, consistent with a neuroprotective action of CI-977 at opioid receptors, presumably of the kappa subtype.[1]

References

  1. The neuroprotective kappa-opioid CI-977 alters glutamate-induced calcium signaling in vitro. DeCoster, M.A., Conover, J.R., Hunter, J.C., Tortella, F.C. Neuroreport (1994) [Pubmed]
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