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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Prospective evaluation of terazosin for the treatment of autonomic dysreflexia.

Terazosin was evaluated in 21 normotensive spinal cord injured patients with autonomic dysreflexia. The patients were followed for 3 months during which the autonomic dysreflexia severity and frequency were evaluated. Autonomic dysreflexia severity mean score was significantly improved when measured at baseline and at 1 week, 1 month and 3 months (10.3 +/- 4.2, 5.08 +/- 2.3, 3.83 +/- 2.5 and 4.5 +/- 1.4, respectively, p < 0.0005). No statistically significant change was seen in erectile function and blood pressure. Three patients complained of fatigue, 1 of whom had the dosage reduced from 5 to 2.5 mg. daily. Terazosin appears to be effective in preventing serious harm from autonomic dysreflexia without erectile function impairment. The effectiveness is significant in the first week and remains for at least 3 months.[1]


  1. Prospective evaluation of terazosin for the treatment of autonomic dysreflexia. Chancellor, M.B., Erhard, M.J., Hirsch, I.H., Stass, W.E. J. Urol. (1994) [Pubmed]
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