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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Azithromycin prophylaxis against a chloroquine-resistant strain of Plasmodium falciparum.

Azithromycin has antimalarial activity and favourable pharmacokinetic properties for a prophylactic antimalarial agent. We investigated the ability of azithromycin to prevent malaria in volunteers infected with a chloroquine-resistant strain of Plasmodium falciparum. 4 volunteers received oral azithromycin 500 mg followed by 250 mg daily for 7 further days. Subjects were infected on the third day of azithromycin. 3 subjects were protected compared with none of 15 controls. The volunteer not protected by azithromycin had unquantifiable plasma levels of azithromycin, probably because of poor absorption. Azithromycin could be a promising prophylactic agent for P falciparum malaria.[1]

References

  1. Azithromycin prophylaxis against a chloroquine-resistant strain of Plasmodium falciparum. Kuschner, R.A., Heppner, D.G., Andersen, S.L., Wellde, B.T., Hall, T., Schneider, I., Ballou, W.R., Foulds, G., Sadoff, J.C., Schuster, B. Lancet (1994) [Pubmed]
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