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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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HER2/neu-derived peptides are shared antigens among human non-small cell lung cancer and ovarian cancer.

Previously, we have reported a correlation between the expression of HER2/neu and sensitivity to HLA-A2-restricted cytotoxic T-cells (CTL) in ovarian cancer. To investigate the role of HER2/neu in human non-small cell lung cancer (NSCLC), we established autologous tumor-specific CTL from tumor-infiltrating lymphocytes of HLA-A2+ HER2/neu+ NSCLC patients. These CTL lines specifically recognized HLA-A2+ HER2/neu+ autologous and allogeneic NSCLC cell lines as well as HLA-A2+ HER2/neu+ heterologous ovarian cancer cell lines. Furthermore, these CTL recognized an overexpressed, HER2/neu-derived peptide. From these results, we conclude that HLA-A2 serves as a restriction element in NSCLC. More importantly, at least one HER2/neu-derived peptide is a tumor-associated antigen in NSCLC and ovarian cancer.[1]

References

  1. HER2/neu-derived peptides are shared antigens among human non-small cell lung cancer and ovarian cancer. Yoshino, I., Goedegebuure, P.S., Peoples, G.E., Parikh, A.S., DiMaio, J.M., Lyerly, H.K., Gazdar, A.F., Eberlein, T.J. Cancer Res. (1994) [Pubmed]
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