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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Stereospecific reduction of R(+)-thioctic acid by porcine heart lipoamide dehydrogenase/diaphorase.

R(+)-thioctic acid is the naturally occurring cofactor in alpha-ketoacid dehydrogenases. We show both photometrically by NADH+H+ oxidation and by HPLC product analysis that this enantiomer is rapidly reduced by NADH+H+ catalyzed by porcine heart lipoamide dehydrogenase/diaphorase. The racemate exhibits approximately 40% activity as compared to the R(+) form while the S(-) enantiomer photometrically shows little activity and yields no detectable reduced lipoic acid.[1]

References

  1. Stereospecific reduction of R(+)-thioctic acid by porcine heart lipoamide dehydrogenase/diaphorase. Schempp, H., Ulrich, H., Elstner, E.F. Z. Naturforsch., C, J. Biosci. (1994) [Pubmed]
 
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