Chemical Compound Review:
lipoic acid 5-[3-(thiolan-3-yl)thiolan-3- yl]pentanoate
Synonyms:
- Autoreactivity to lipoate and a conjugated form of lipoate in primary biliary cirrhosis. Bruggraber, S.F., Leung, P.S., Amano, K., Quan, C., Kurth, M.J., Nantz, M.H., Benson, G.D., Van de Water, J., Luketic, V., Roche, T.E., Ansari, A.A., Coppel, R.L., Gershwin, M.E. Gastroenterology (2003)
- Repeating functional domains in the pyruvate dehydrogenase multienzyme complex of Escherichia coli. Packman, L.C., Hale, G., Perham, R.N. EMBO J. (1984)
- The Mycobacterium tuberculosis LipB enzyme functions as a cysteine/lysine dyad acyltransferase. Ma, Q., Zhao, X., Eddine, A.N., Geerlof, A., Li, X., Cronan, J.E., Kaufmann, S.H., Wilmanns, M. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Cu2+ toxicity inhibition of mitochondrial dehydrogenases in vitro and in vivo. Sheline, C.T., Choi, D.W. Ann. Neurol. (2004)
- Lipoic acid as a novel treatment for Alzheimer's disease and related dementias. Holmquist, L., Stuchbury, G., Berbaum, K., Muscat, S., Young, S., Hager, K., Engel, J., M??nch, G. Pharmacol. Ther. (2007)
- Dietary modulation of age-related changes in cerebral pro-oxidant status. Bondy, S.C., Yang, Y.E., Walsh, T.J., Gie, Y.W., Lahiri, D.K. Neurochem. Int. (2002)
- Lipoic acid improves survival in transgenic mouse models of Huntington's disease. Andreassen, O.A., Ferrante, R.J., Dedeoglu, A., Beal, M.F. Neuroreport (2001)
- (r)-, but not (s)-alpha lipoic acid stimulates deficient brain pyruvate dehydrogenase complex in vascular dementia, but not in Alzheimer dementia. Frölich, L., Götz, M.E., Weinmüller, M., Youdim, M.B., Barth, N., Dirr, A., Gsell, W., Jellinger, K., Beckmann, H., Riederer, P. Journal of neural transmission (Vienna, Austria : 1996) (2004)
- Alpha lipoic acid for dementia. Sauer, J., Tabet, N., Howard, R. Cochrane database of systematic reviews (Online) (2004)
- Allosteric modulation of the NMDA receptor by dihydrolipoic and lipoic acid in rat cortical neurons in vitro. Tang, L.H., Aizenman, E. Neuron (1993)
- Primary biliary cirrhosis: paradigm or paradox for autoimmunity. Gershwin, M.E., Mackay, I.R. Gastroenterology (1991)
- A lipoic acid-gamma linolenic acid conjugate is effective against multiple indices of experimental diabetic neuropathy. Hounsom, L., Horrobin, D.F., Tritschler, H., Corder, R., Tomlinson, D.R. Diabetologia (1998)
- The role of lipoic acid residues in the pyruvate dehydrogenase multienzyme complex of Escherichia coli. Danson, M.J., Hale, G., Perham, R.N. Biochem. J. (1981)
- Lipoic acid supplementation prevents angiotensin II-induced renal injury. Mervaala, E., Finckenberg, P., Lapatto, R., Müller, D.N., Park, J.K., Dechend, R., Ganten, D., Vapaatalo, H., Luft, F.C. Kidney Int. (2003)
- Lipoylating and biotinylating enzymes contain a homologous catalytic module. Reche, P.A. Protein Sci. (2000)
- Lipoic acid metabolism in Escherichia coli: isolation of null mutants defective in lipoic acid biosynthesis, molecular cloning and characterization of the E. coli lip locus, and identification of the lipoylated protein of the glycine cleavage system. Vanden Boom, T.J., Reed, K.E., Cronan, J.E. J. Bacteriol. (1991)
- Mutations in PDX1, the human lipoyl-containing component X of the pyruvate dehydrogenase-complex gene on chromosome 11p1, in congenital lactic acidosis. Aral, B., Benelli, C., Ait-Ghezala, G., Amessou, M., Fouque, F., Maunoury, C., Créau, N., Kamoun, P., Marsac, C. Am. J. Hum. Genet. (1997)
- Mutants of Escherichia coli K-12 that are resistant to a selenium analog of lipoic acid identify unknown genes in lipoate metabolism. Reed, K.E., Morris, T.W., Cronan, J.E. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acid. Suh, J.H., Shigeno, E.T., Morrow, J.D., Cox, B., Rocha, A.E., Frei, B., Hagen, T.M. FASEB J. (2001)
- Primary biliary cirrhosis: identification of two major M2 mitochondrial autoantigens. Yeaman, S.J., Fussey, S.P., Danner, D.J., James, O.F., Mutimer, D.J., Bassendine, M.F. Lancet (1988)
- Toxoplasma gondii scavenges host-derived lipoic acid despite its de novo synthesis in the apicoplast. Crawford, M.J., Thomsen-Zieger, N., Ray, M., Schachtner, J., Roos, D.S., Seeber, F. EMBO J. (2006)
- Synthesis and characterization of selenotrisulfide-derivatives of lipoic acid and lipoamide. Self, W.T., Tsai, L., Stadtman, T.C. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Suh, J.H., Shenvi, S.V., Dixon, B.M., Liu, H., Jaiswal, A.K., Liu, R.M., Hagen, T.M. Proc. Natl. Acad. Sci. U.S.A. (2004)
- X-ray structure determination at 2.6-A resolution of a lipoate-containing protein: the H-protein of the glycine decarboxylase complex from pea leaves. Pares, S., Cohen-Addad, C., Sieker, L., Neuburger, M., Douce, R. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Regulation of pyruvate dehydrogenase kinase activity by protein thiol-disulfide exchange. Pettit, F.H., Humphreys, J., Reed, L.J. Proc. Natl. Acad. Sci. U.S.A. (1982)
- Site-directed mutagenesis of lysine within the immunodominant autoepitope of PDC-E2. Leung, P.S., Iwayama, T., Coppel, R.L., Gershwin, M.E. Hepatology (1990)
- Isolation and characterization of LIP5. A lipoate biosynthetic locus of Saccharomyces cerevisiae. Sulo, P., Martin, N.C. J. Biol. Chem. (1993)
- A novel phosphopantetheine:protein transferase activating yeast mitochondrial acyl carrier protein. Stuible, H.P., Meier, S., Wagner, C., Hannappel, E., Schweizer, E. J. Biol. Chem. (1998)
- Facilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferase. Hiromasa, Y., Roche, T.E. J. Biol. Chem. (2003)
- IRS1 degradation and increased serine phosphorylation cannot predict the degree of metabolic insulin resistance induced by oxidative stress. Potashnik, R., Bloch-Damti, A., Bashan, N., Rudich, A. Diabetologia (2003)
- Antimitochondrial antibodies in primary biliary cirrhosis recognize both specific peptides and shared epitopes of the M2 family of antigens. Flannery, G.R., Burroughs, A.K., Butler, P., Chelliah, J., Hamilton-Miller, J., Brumfitt, W., Baum, H. Hepatology (1989)
- Characterization of the autoantibody responses to recombinant E3 binding protein (protein X) of pyruvate dehydrogenase in primary biliary cirrhosis. Palmer, J.M., Jones, D.E., Quinn, J., McHugh, A., Yeaman, S.J. Hepatology (1999)
- A lipoyl synthetic octadecapeptide of dihydrolipoamide acetyltransferase specifically recognized by anti-M2 autoantibodies in primary biliary cirrhosis. Tuaillon, N., Andre, C., Briand, J.P., Penner, E., Muller, S. J. Immunol. (1992)
- Primary biliary cirrhosis. Inhibition of pyruvate dehydrogenase complex activity by autoantibodies specific for E1 alpha, a non-lipoic acid containing mitochondrial enzyme. Fregeau, D.R., Roche, T.E., Davis, P.A., Coppel, R., Gershwin, M.E. J. Immunol. (1990)
- The human malaria parasite Plasmodium falciparum has distinct organelle-specific lipoylation pathways. Wrenger, C., Müller, S. Mol. Microbiol. (2004)